Hmdb loader

HMDBP02052 (Bile salt export pump) Metabolite Associations

Displaying metabolite protein links 1 - 25 of 105 in total
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0014644Cimetidine51481-61-9ThumbC10H16N6S252.339
252.115715232
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
HMDB0014620Chlorpromazine50-53-3ThumbC17H19ClN2S318.864
318.095747015
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
HMDB0014831Fluorescein2321-07-5ThumbC20H12O5332.3063
332.068473494
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
HMDB0015044Quinidine56-54-2ThumbC20H24N2O2324.4168
324.183778022
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
HMDB000192617a-Ethynylestradiol57-63-6ThumbC20H24O2296.4034
296.177630012
  1. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan;118(1):163-72. [PubMed:10611165 ]
  2. Huang L, Smit JW, Meijer DK, Vore M: Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. Hepatology. 2000 Jul;32(1):66-72. [PubMed:10869290 ]
HMDB0001830Progesterone57-83-0ThumbC21H30O2314.4617
314.224580204
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
HMDB0015364Dexamethasone50-02-2ThumbC22H29FO5392.4611
392.199902243
  1. Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V: Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology. 2001 Oct 5;167(1):37-46. [PubMed:11557128 ]
HMDB0002082Bisnorcholic acidThumbC22H36O5380.5182
380.256274262		Not Available
HMDB0015151Glyburide10238-21-8ThumbC23H28ClN3O5S494.004
493.143819418
  1. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. [PubMed:10648470 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
  3. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. [PubMed:12404239 ]
  4. Kemp DC, Brouwer KL: Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. Toxicol In Vitro. 2004 Dec;18(6):869-77. [PubMed:15465654 ]
  5. Horikawa M, Kato Y, Tyson CA, Sugiyama Y: Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet. 2003;18(1):16-22. [PubMed:15618715 ]
  6. Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. [PubMed:11343252 ]
  7. Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology. 2001 Oct 5;167(1):83-98. [PubMed:11557132 ]
HMDB00025043-Sulfodeoxycholic acid67030-48-2ThumbC23H38O7S458.609
458.23382426		Not Available
HMDB00004763-Oxo-4,6-choladienoic acid88179-71-9ThumbC24H34O3370.525
370.250794954		Not Available
HMDB000038512a-Hydroxy-3-oxocholadienic acid13535-96-1ThumbC24H34O4386.5244
386.245709576		Not Available
HMDB00004477a,12a-Dihydroxy-3-oxo-4-cholenoic acid13587-11-6ThumbC24H36O5404.5396
404.256274262		Not Available
HMDB00003083b-Hydroxy-5-cholenoic acid5255-17-4ThumbC24H38O3374.5567
374.282095082		Not Available
HMDB000032812-Ketodeoxycholic acid5130-29-0ThumbC24H38O4390.5561
390.277009704		Not Available
HMDB00004607-Hydroxy-3-oxocholanoic acid77059-13-3ThumbC24H38O4390.5561
390.277009704		Not Available
HMDB0000467Nutriacholic acid4651-67-6ThumbC24H38O4390.5561
390.277009704		Not Available
HMDB00005037alpha-Hydroxy-3-oxo-5beta-cholan-24-oic acid4185-00-6ThumbC24H38O4390.564
390.277009704		Not Available
HMDB00003917-Ketodeoxycholic acid911-40-0ThumbC24H38O5406.5555
406.271924326		Not Available
HMDB00004003,7-Dihydroxy-12-oxocholanoic acid2458-08-4ThumbC24H38O5406.5555
406.271924326		Not Available
HMDB00005023-Oxocholic acid2304-89-4ThumbC24H38O5406.563
406.271924324		Not Available
HMDB0000545Chenodeoxycholic acid disulfate60262-91-1ThumbC24H40O10S2552.698
552.20628888		Not Available
HMDB0000659Deoxycholic acid disulfate67030-51-7ThumbC24H40O10S2552.698
552.20628888		Not Available
HMDB0000381Allolithocholic acid2276-94-0ThumbC24H40O3376.5726
376.297745146		Not Available
HMDB0000713Isoallolithocholic acid2276-93-9ThumbC24H40O3376.5726
376.297745146		Not Available
Displaying metabolite protein links 1 - 25 of 105 in total