Hmdb loader
Identification
HMDB Protein ID HMDBP01818
Secondary Accession Numbers
  • 7179
Name Glutamate receptor, ionotropic kainate 3
Synonyms
  1. EAA5
  2. Excitatory amino acid receptor 5
  3. GluR-7
  4. GluR7
  5. Glutamate receptor 7
Gene Name GRIK3
Protein Type Enzyme
Biological Properties
General Function Involved in ionotropic glutamate receptor activity
Specific Function Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
receptor activity
transmembrane receptor activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
molecular transducer activity
signal transducer activity
transporter activity
ion channel activity
ligand-gated ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ionotropic glutamate receptor activity
Process
establishment of localization
transport
ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
  3. Multi-pass membrane protein
  4. Cell junction
  5. synapse
  6. postsynaptic cell membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 1p34-p33
SNPs GRIK3
Gene Sequence
>2760 bp
ATGACCGCTCCCTGGCGGCGCCTCCGGAGTCTGGTTTGGGAATACTGGGCCGGGCTCCTC
GTGTGCGCCTTCTGGATCCCGGACTCGCGCGGGATGCCCCACGTCATCCGGATCGGAGGA
ATCTTCGAGTATGCGGACGGCCCCAACGCCCAGGTCATGAATGCCGAGGAGCATGCCTTT
CGATTTTCTGCCAACATCATCAACAGGAACAGGACTCTGCTGCCCAACACAACCTTGACC
TATGACATACAGAGGATTCACTTCCATGACAGCTTCGAGGCGACCAAAAAGGCCTGTGAC
CAGCTGGCACTGGGCGTGGTGGCGATCTTCGGCCCATCACAGGGCTCCTGCACCAATGCC
GTCCAGTCCATCTGCAATGCCCTGGAGGTGCCCCACATCCAGCTGCGTTGGAAGCACCAC
CCGCTGGACAACAAGGACACCTTCTACGTGAACCTCTACCCCGACTACGCCTCGCTCAGC
CATGCCATCCTCGACCTGGTCCAGTACCTCAAGTGGCGGTCAGCCACCGTGGTCTATGAC
GACAGTACAGGGCTCATCCGACTGCAGGAGCTCATCATGGCCCCATCAAGATACAACATC
CGCCTGAAGATCCGTCAGCTCCCCATCGACTCTGACGACTCGCGCCCCTTGCTCAAGGAG
ATGAAGCGAGGCCGGGAATTCCGCATTATCTTCGACTGCAGCCACACTATGGCGGCCCAG
ATCCTCAAGCAGGCCATGGCCATGGGCATGATGACTGAGTACTACCACTTCATCTTCACC
ACTCTGGATCTCTACGCTTTAGACCTGGAGCCCTACCGCTACTCAGGCGTGAACCTGACA
GGATTCCGGATTCTCAATGTGGACAACCCACACGTCTCGGCCATTGTGGAGAAGTGGTCC
ATGGAGCGGCTGCAGGCAGCTCCCCGGTCCGAGTCTGGCCTGCTGGATGGAGTGATGATG
ACTGATGCAGCCTTACTGTACGACGCCGTCCATATCGTGTCCGTGTGCTACCAGCGGGCA
CCACAGATGACCGTGAACTCCCTGCAGTGCCATCGGCACAAGGCCTGGCGCTTTGGCGGC
CGCTTCATGAACTTCATCAAGGAGGCTCAATGGGAAGGATTAACTGGACGAATTGTTTTC
AACAAAACTAGTGGCTTGCGGACGGATTTTGATCTGGACATCATCAGCCTGAAAGAGGAT
GGCCTGGAGAAGGTTGGGGTGTGGAGTCCTGCCGACGGGCTCAACATCACTGAGGTTGCC
AAAGGCCGAGGCCCTAATGTCACCGACTCTCTGACAAACAGATCACTCATTGTCACCACA
GTGCTGGAGGAGCCCTTCGTCATGTTTCGGAAATCAGACAGGACGCTATACGGGAATGAC
CGGTTCGAGGGCTACTGCATCGACCTGCTAAAGGAGCTGGCCCACATCCTTGGTTTCTCC
TATGAGATCCGGCTGGTGGAGGACGGCAAGTACGGGGCACAGGATGACAAGGGCCAGTGG
AACGGCATGGTCAAGGAGCTCATCGACCACAAGGCAGATCTGGCCGTGGCCCCCCTGACC
ATCACCCATGTTCGAGAGAAGGCCATCGACTTCTCCAAGCCCTTCATGACACTTGGTGTG
AGCATCCTGTATCGAAAGCCCAATGGCACCAACCCCAGCGTCTTCTCCTTCCTCAATCCC
CTGTCCCCAGACATCTGGATGTATGTTCTCCTCGCCTACCTGGGGGTCAGCTGTGTCCTC
TTCGTCATCGCCAGGTTCAGCCCTTATGAGTGGTACGATGCTCACCCCTGCAACCCTGGC
TCCGAGGTGGTGGAAAATAACTTCACTCTGCTTAACAGCTTCTGGTTTGGAATGGGATCC
CTGATGCAGCAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGC
ATCTGGTGGTTCTTCACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTT
CTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGACCTGGCCAAGCAAACC
AAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAG
ATCTCCACCTTCGAGAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAG
AACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGCGCTGCTCATGGAGTCC
ACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATT
GACTCCAAGGGCTACGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACC
ATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCATGAAGGAGAAGTGGTGG
CGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAG
ATCGGGGGCATCTTCATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTG
GGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCAGCGTTCCTTCTGCAGC
ACCGTGGCCGATGAGATCCGTTTCTCCCTTACCTGCCAGCGTCGAGTCAAGCACAAGCCT
CAGCCTCCCATGATGGTCAAGACTGACGCCGTCATCAACATGCACACATTCAATGACCGC
CGGCTTCCCGGCAAGGACAGCATGGCCTGCAGCACATCCTTAGCCCCTGTGTTCCCCTAG
Protein Properties
Number of Residues 919
Molecular Weight 104036.1
Theoretical pI 7.55
Pfam Domain Function
Signals
  • 1-31
Transmembrane Regions
  • 564-584
  • 637-657
  • 821-841
Protein Sequence
>Glutamate receptor, ionotropic kainate 3
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
GenBank ID Protein 56205347
UniProtKB/Swiss-Prot ID Q13003
UniProtKB/Swiss-Prot Entry Name GRIK3_HUMAN
PDB IDs
GenBank Gene ID AL355386
GeneCard ID GRIK3
GenAtlas ID GRIK3
HGNC ID HGNC:4581
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  2. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  3. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  4. Wang Y, Du D, Fang L, Yang G, Zhang C, Zeng R, Ullrich A, Lottspeich F, Chen Z: Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 2006 Nov 1;25(21):5058-70. Epub 2006 Oct 19. [PubMed:17053785 ]
  5. Nutt SL, Hoo KH, Rampersad V, Deverill RM, Elliott CE, Fletcher EJ, Adams SL, Korczak B, Foldes RL, Kamboj RK: Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Receptors Channels. 1994;2(4):315-26. [PubMed:7719709 ]
  6. Puranam RS, Eubanks JH, Heinemann SF, McNamara JO: Chromosomal localization of gene for human glutamate receptor subunit-7. Somat Cell Mol Genet. 1993 Nov;19(6):581-8. [PubMed:8128318 ]
  7. Schiffer HH, Swanson GT, Masliah E, Heinemann SF: Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. J Neurosci. 2000 Dec 15;20(24):9025-33. [PubMed:11124978 ]