Hmdb loader

HMDBP00428 (Thiopurine S-methyltransferase) Metabolite Associations

Displaying all 12 metabolite protein links
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0000939S-Adenosylhomocysteine979-92-0ThumbC14H20N6O5S384.411
384.12158847		Not Available
HMDB0001185S-Adenosylmethionine485-80-3ThumbC15H23N6O5S399.445
399.145063566		Not Available
HMDB0014580Bendroflumethiazide73-48-3ThumbC15H14F3N3O4S2421.415
421.037781946
  1. Lysaa RA, Giverhaug T, Wold HL, Aarbakke J: Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol. 1996;49(5):393-6. [PubMed:8866635 ]
HMDB0015128Azathioprine446-86-6ThumbC9H7N7O2S277.263
277.038193193
  1. Sahasranaman S, Howard D, Roy S: Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. doi: 10.1007/s00228-008-0478-6. Epub 2008 May 28. [PubMed:18506437 ]
HMDB0015167Mercaptopurine50-44-2ThumbC5H4N4S152.177
152.015666838
  1. Dubinsky MC: Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731-43. [PubMed:15354273 ]
HMDB0015380Olsalazine15722-48-2ThumbC14H10N2O6302.239
302.053886062
  1. Lewis LD, Benin A, Szumlanski CL, Otterness DM, Lennard L, Weinshilboum RM, Nierenberg DW: Olsalazine and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction. Clin Pharmacol Ther. 1997 Oct;62(4):464-75. [PubMed:9357398 ]
  2. Lennard L: TPMT in the treatment of Crohn's disease with azathioprine. Gut. 2002 Aug;51(2):143-6. [PubMed:12117866 ]
  3. Lennard L: Clinical implications of thiopurine methyltransferase--optimization of drug dosage and potential drug interactions. Ther Drug Monit. 1998 Oct;20(5):527-31. [PubMed:9780130 ]
  4. Shipkova M, Niedmann PD, Armstrong VW, Oellerich M, Wieland E: Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine. Clin Chem. 2004 Feb;50(2):438-41. [PubMed:14752016 ]
HMDB0015422Cefazolin25953-19-9ThumbC14H14N8O4S3454.507
454.030013046
  1. Kerremans AL, Lipsky JJ, Van Loon J, Gallego MO, Weinshilboum RM: Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol. J Pharmacol Exp Ther. 1985 Nov;235(2):382-8. [PubMed:2865352 ]
  2. Wood TC, Johnson KL, Naylor S, Weinshilboum RM: Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8. [PubMed:12228189 ]
HMDB00604126-MethylmercaptopurineThumbC6H6N4S166.204
166.031316902		Not Available
HMDB00604136-Methylthioguanosine monophosphateThumbC11H16N5O7PS393.313
393.050805093		Not Available
HMDB00604146-Methylthiopurine 5'-monophosphate ribonucleotide7021-52-5ThumbC11H15N4O7PS378.298
378.039906056		Not Available
HMDB00604156-Thioguanosine monophosphateThumbC10H14N5O7PS379.286
379.035155029		Not Available
HMDB00604166-Thioinosine-5'-monophosphateThumbC10H13N4O7PS364.272
364.024255992		Not Available
Displaying all 12 metabolite protein links