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Showing Protein Protein-S-isoprenylcysteine O-methyltransferase (HMDBP00414)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP00414
Secondary Accession Numbers
  • 5651
Name Protein-S-isoprenylcysteine O-methyltransferase
Synonyms
  1. Isoprenylcysteine carboxylmethyltransferase
  2. PPMT
  3. Prenylated protein carboxyl methyltransferase
  4. Prenylcysteine carboxyl methyltransferase
  5. pcCMT
Gene Name ICMT
Protein Type Unknown
Biological Properties
General Function Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Specific Function Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Pathways
  • Terpenoid backbone biosynthesis
Reactions
S-Adenosylmethionine + protein C-terminal S-farnesyl-L-cysteine → S-Adenosylhomocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester details
GO Classification
Biological Process
positive regulation of cell proliferation
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
in utero embryonic development
liver development
protein targeting to membrane
regulation of Ras protein signal transduction
multicellular organism growth
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
transferase activity
protein methyltransferase activity
protein carboxyl o-methyltransferase activity
protein c-terminal carboxyl o-methyltransferase activity
protein c-terminal s-isoprenylcysteine carboxyl o-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
cAMP response element binding protein binding
protein C-terminal carboxyl O-methyltransferase activity
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Process
metabolic process
macromolecule metabolic process
post-translational protein modification
protein amino acid alkylation
protein amino acid methylation
c-terminal protein amino acid methylation
macromolecule modification
protein modification process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 1
Locus 1p36.21
SNPs ICMT
Gene Sequence 
>855 bp
ATGGCGGGCTGCGCGGCGCGGGCTCCGCCGGGCTCTGAGGCGCGTCTCAGCCTCGCCACC
TTCCTGCTGGGCGCCTCGGTGCTCGCGCTGCCGCTGCTCACGCGCGCCGGCCTGCAGGGC
CGCACCGGGCTGGCGCTCTACGTGGCCGGGCTCAACGCGCTGCTGCTGCTGCTCTATCGG
CCGCCTCGCTACCAGATAGCCATCCGAGCTTGTTTCCTGGGGTTTGTGTTCGGCTGCGGC
ACGCTGCTAAGTTTTAGCCAGTCTTCTTGGAGTCACTTTGGCTGGTACATGTGCTCCCTG
TCATTGTTCCACTATTCTGAATACTTGGTGACAGCAGTCAATAATCCCAAAAGTCTGTCC
TTGGATTCCTTTCTCCTGAATCACAGCCTGGAGTATACAGTAGCTGCTCTTTCTTCTTGG
TTAGAGTTCACACTTGAAAATATCTTTTGGCCAGAACTGAAGCAGATTACCTGGCTCAGT
GTCACAGGGCTGCTGATGGTGGTCTTCGGAGAATGTCTGAGGAAGGCGGCCATGTTTACA
GCTGGCTCCAATTTCAACCACGTGGTACAGAATGAAAAATCAGATACACATACTCTGGTG
ACCAGTGGAGTGTACGCTTGGTTTCGGCATCCTTCTTACGTCGGGTGGTTTTACTGGAGT
ATTGGAACTCAGGTGATGCTGTGTAACCCCATCTGCGGCGTCAGCTATGCCCTGACAGTG
TGGCGATTCTTCCGCGATCGAACAGAAGAAGAAGAAATCTCACTAATTCACTTTTTTGGA
GAGGAGTACCTGGAGTATAAGAAGAGGGTGCCCACGGGCCTGCCTTTCATAAAGGGGGTC
AAGGTGGACCTGTGA
Protein Properties
Number of Residues 284
Molecular Weight 31937.775
Theoretical pI 7.961
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Protein-S-isoprenylcysteine O-methyltransferase
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
GenBank ID Protein 3135669
UniProtKB/Swiss-Prot ID O60725
UniProtKB/Swiss-Prot Entry Name ICMT_HUMAN
PDB IDs Not Available
GenBank Gene ID AF064084
GeneCard ID ICMT
GenAtlas ID ICMT
HGNC ID HGNC:5350
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR: Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12;273(24):15030-4. [PubMed:9614111 ]
  3. Lin X, Antalffy B, Kang D, Orr HT, Zoghbi HY: Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat Neurosci. 2000 Feb;3(2):157-63. [PubMed:10649571 ]