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Showing Protein Diphthine synthase (HMDBP00407)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 5 metabolites
Identification
HMDB Protein ID HMDBP00407
Secondary Accession Numbers
  • 5644
Name Diphthine synthase
Synonyms
  1. Diphthamide biosynthesis methyltransferase
Gene Name DPH5
Protein Type Unknown
Biological Properties
General Function Involved in methyltransferase activity
Specific Function S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
Pathways
  • peptidyl-diphthamide biosynthesis
Reactions
S-Adenosylmethionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine → S-Adenosylhomocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine details
GO Classification
Biological Process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Function
catalytic activity
transferase activity
s-adenosylmethionine-dependent methyltransferase activity
diphthine synthase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
diphthine synthase activity
Process
metabolic process
macromolecule metabolic process
peptidyl-histidine modification
peptidyl-diphthamide metabolic process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
macromolecule modification
protein modification process
peptidyl-amino acid modification
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus 1p21.2
SNPs DPH5
Gene Sequence 
>858 bp
ATGCTTTATCTCATCGGGTTGGGCCTGGGAGATGCCAAGGACATCACAGTCAAGGGCCTG
GAAGTTGTTAGACGCTGCAGTCGAGTGTATCTGGAAGCCTACACCTCAGTCCTAACTGTA
GGGAAGGAAGCCTTGGAAGAGTTTTATGGAAGAAAATTGGTTGTTGCTGATAGAGAAGAA
GTGGAACAAGAAGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTT
GTGGTTGGTGATCCATTTGGGGCCACAACACACAGTGATCTTGTTCTAAGAGCAACAAAG
CTGGGAATTCCTTATAGAGTTATTCACAATGCCTCCATAATGAATGCTGTAGGCTGCTGT
GGTTTACAGTTATATAAGTTTGGAGAGACAGTTTCTATTGTTTTTTGGACAGACACTTGG
AGACCAGAAAGCTTCTTTGACAAAGTGAAGAAGAACAGACAAAATGGCATGCACACATTA
TGTTTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAATCTAATCAAGGGAAGGAAG
ATCTATGAACCTCCACGGTATATGAGTGTAAACCAAGCAGCCCAGCAGCTTCTGGAGATT
GTTCAAAATCAAAGAATACGAGGAGAAGAACCAGCAGTTACCGAGGAGACACTTTGTGTT
GGCTTAGCCAGGGTTGGAGCCGACGACCAGAAAATTGCAGCAGGCACTTTAAGGCAAATG
TGCACTGTGGACTTGGGAGAACCATTGCATTCCTTGATCATCACAGGAGGCAGCATACAT
CCAATGGAGATGGAGATGCTAAGTCTGTTTTCCATACCAGAAAATAGCTCAGAATCTCAA
AGCATCAATGGACTTTGA
Protein Properties
Number of Residues 285
Molecular Weight 31651.17
Theoretical pI 5.307
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Diphthine synthase
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE
VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC
GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK
IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM
CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
GenBank ID Protein 117190326
UniProtKB/Swiss-Prot ID Q9H2P9
UniProtKB/Swiss-Prot Entry Name DPH5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001077394.1
GeneCard ID DPH5
GenAtlas ID DPH5
HGNC ID HGNC:24270
References
General References
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