| HMDB0000217 | NADP | 53-59-8 |  | C21H28N7O17P3 | 743.405
743.075452041 | Not Available |
| HMDB0000221 | NADPH | 53-57-6 |  | C21H30N7O17P3 | 745.4209
745.091102105 | Not Available |
| HMDB0001248 | FAD | 146-14-5 |  | C27H33N9O15P2 | 785.5497
785.157134455 | Not Available |
| HMDB0001451 | (R)-Lipoic acid | 1200-22-2 |  | C8H14O2S2 | 206.326
206.043521072 | Not Available |
| HMDB0001520 | Flavin mononucleotide | 146-17-8 |  | C17H21N4O9P | 456.3438
456.104614802 | - Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
|
| HMDB0001892 | Menadione | 58-27-5 |  | C11H8O2 | 172.18
172.0524295 | Not Available |
| HMDB0003178 | Heme | 14875-96-8 |  | C34H32FeN4O4 | 616.487
616.177297665 | Not Available |
| HMDB0012947 | Ferrocytochrome | 1818-68-4 |  | C33H32FeN4O4 | 604.487
604.176194 | Not Available |
| HMDB0014312 | (S)-Lipoic acid | 1077-27-6 |  | C8H14O2S2 | 206.326
206.043521072 | - Dudka J: Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid. Ann Nutr Metab. 2006;50(2):121-5. Epub 2006 Jan 2. [PubMed:16391466 ]
- Wen B, Coe KJ, Rademacher P, Fitch WL, Monshouwer M, Nelson SD: Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase. Chem Res Toxicol. 2008 Dec;21(12):2393-406. doi: 10.1021/tx800281h. [PubMed:19548358 ]
- Gan L, von Moltke LL, Trepanier LA, Harmatz JS, Greenblatt DJ, Court MH: Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes. Drug Metab Dispos. 2009 Jan;37(1):90-6. doi: 10.1124/dmd.108.023424. Epub 2008 Oct 6. [PubMed:18838505 ]
|
| HMDB0014450 | Mitomycin | 50-07-7 |  | C15H18N4O5 | 334.3272
334.127719706 | - Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR: Activation of mitomycin C by NADPH:cytochrome P-450 reductase. Cancer Res. 1990 Dec 15;50(24):7789-92. [PubMed:2123741 ]
- Vromans RM, van de Straat R, Groeneveld M, Vermeulen NP: One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase. Xenobiotica. 1990 Sep;20(9):967-78. [PubMed:2122607 ]
|
| HMDB0014803 | Nilutamide | 63612-50-0 |  | C12H10F3N3O4 | 317.2207
317.062340438 | - Berger V, Berson A, Wolf C, Chachaty C, Fau D, Fromenty B, Pessayre D: Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. Biochem Pharmacol. 1992 Feb 4;43(3):654-7. [PubMed:1311586 ]
|
| HMDB0014832 | Daunorubicin | 20830-81-3 |  | C27H29NO10 | 527.5199
527.179146153 | - Bachur NR, Gordon SL, Gee MV, Kon H: NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci U S A. 1979 Feb;76(2):954-7. [PubMed:34156 ]
- Di Re J, Lee C, Riddick DS: Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin. Can J Physiol Pharmacol. 1999 Aug;77(8):589-97. [PubMed:10543722 ]
|
| HMDB0014836 | Nitrofurantoin | 67-20-9 |  | C8H6N4O5 | 238.157
238.033819322 | - Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD: Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79. doi: 10.1016/j.freeradbiomed.2007.12.013. Epub 2007 Dec 23. [PubMed:18206659 ]
|
| HMDB0015003 | Benzphetamine | 156-08-1 |  | C17H21N | 239.3553
239.167399677 | - Kanaeva IP, Nikityuk OV, Davydov DR, Dedinskii IR, Koen YM, Kuznetsova GP, Skotselyas ED, Bachmanova GI, Archakov AI: Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. II. Kinetic parameters of reductase and monooxygenase reactions. Arch Biochem Biophys. 1992 Nov 1;298(2):403-12. [PubMed:1416971 ]
- Matsumoto T, Emi Y, Kawabata S, Omura T: Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. J Biochem. 1986 Nov;100(5):1359-71. [PubMed:2434473 ]
- Kojima H, Takahashi K, Sakane F, Koyama J: Purification and characterization of NADPH-cytochrome c reductase from porcine polymorphonuclear leukocytes. J Biochem. 1987 Nov;102(5):1083-8. [PubMed:3125159 ]
- Dutton DR, McMillen SK, Parkinson A: Purification of rat liver microsomal cytochrome P-450b without the use of nonionic detergent. J Biochem Toxicol. 1988 Summer;3:131-45. [PubMed:3148724 ]
- Halpert JR, Miller NE, Gorsky LD: On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem. 1985 Jul 15;260(14):8397-403. [PubMed:3924914 ]
|
| HMDB0015509 | Ethylmorphine | 76-58-4 |  | C19H23NO3 | 313.3908
313.167793607 | Not Available |
