Showing Protein Prostaglandin E synthase (HMDBP00079)

• 5308

1. MGST1-L1
2. Microsomal glutathione S-transferase 1-like 1
3. p53-induced gene 12 protein
4. Microsomal prostaglandin E synthase 1
5. MPGES-1

• Acetaminophen Action Pathway
• Acetylsalicylic Acid Action Pathway
• Antipyrine Action Pathway
• Antrafenine Action Pathway
• Arachidonic acid metabolism
• Arachidonic Acid Metabolism
• Bromfenac Action Pathway
• Carprofen Action Pathway
• Celecoxib Action Pathway
• Diclofenac Action Pathway
• Diflunisal Action Pathway
• Etodolac Action Pathway
• Etoricoxib Action Pathway
• Fenoprofen Action Pathway
• Flurbiprofen Action Pathway
• Ibuprofen Action Pathway
• Indomethacin Action Pathway
• Ketoprofen Action Pathway
• Ketorolac Action Pathway
• Leukotriene C4 Synthesis Deficiency
• Lornoxicam Action Pathway
• Lumiracoxib Action Pathway
• Magnesium salicylate Action Pathway
• Mefenamic Acid Action Pathway
• Meloxicam Action Pathway
• Nabumetone Action Pathway
• Naproxen Action Pathway
• Nepafenac Action Pathway
• Oxaprozin Action Pathway
• Phenylbutazone Action Pathway
• Piroxicam Action Pathway
• Rofecoxib Action Pathway
• Salicylate-sodium Action Pathway
• Salicylic Acid Action Pathway
• Salsalate Action Pathway
• Sulindac Action Pathway
• Suprofen Action Pathway
• Tenoxicam Action Pathway
• Tiaprofenic Acid Action Pathway
• Tolmetin Action Pathway
• Trisalicylate-choline Action Pathway
• Valdecoxib Action Pathway

1. Membrane
2. Multi-pass membrane protein (Potential)

>459 bp
ATGCCTGCCCACAGCCTGGTGATGAGCAGCCCGGCCCTCCCGGCCTTCCTGCTCTGCAGC
ACGCTGCTGGTCATCAAGATGTACGTGGTGGCCATCATCACGGGCCAAGTGAGGCTGCGG
AAGAAGGCCTTTGCCAACCCCGAGGATGCCCTGAGACACGGAGGCCCCCAGTATTGCAGG
AGCGACCCCGACGTGGAACGCTGCCTCAGGGCCCACCGGAACGACATGGAGACCATCTAC
CCCTTCCTTTTCCTGGGCTTCGTCTACTCCTTTCTGGGTCCTAACCCTTTTGTCGCCTGG
ATGCACTTCCTGGTCTTCCTCGTGGGCCGTGTGGCACACACCGTGGCCTACCTGGGGAAG
CTGCGGGCACCCATCCGCTCCGTGACCTACACCCTGGCCCAGCTCCCCTGCGCCTCCATG
GCTCTGCAGATCCTCTGGGAAGCGGCCCGCCACCTGTGA

• MAPEG (PF01124 )

>Prostaglandin E synthase
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL

• 3DWW

1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
2. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B: A model for p53-induced apoptosis. Nature. 1997 Sep 18;389(6648):300-5. [PubMed:9305847 ]
3. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B: Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7220-5. [PubMed:10377395 ]
4. Forsberg L, Leeb L, Thoren S, Morgenstern R, Jakobsson P: Human glutathione dependent prostaglandin E synthase: gene structure and regulation. FEBS Lett. 2000 Apr 7;471(1):78-82. [PubMed:10760517 ]
5. Ouellet M, Falgueyret JP, Ear PH, Pen A, Mancini JA, Riendeau D, Percival MD: Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif. 2002 Dec;26(3):489-95. [PubMed:12460774 ]
6. Thoren S, Weinander R, Saha S, Jegerschold C, Pettersson PL, Samuelsson B, Hebert H, Hamberg M, Morgenstern R, Jakobsson PJ: Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209. Epub 2003 Apr 2. [PubMed:12672824 ]