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Showing metabocard for Methamphetamine (HMDB0015517)

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enzymes (10)transporters (4) Show 14 proteins
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:52 UTC
Update Date2023-02-21 17:18:31 UTC
HMDB IDHMDB0015517
Secondary Accession Numbers
  • HMDB15517
Metabolite Identification
Common NameMethamphetamine
DescriptionMethamphetamine, also known as D-deoxyephedrine or metamfetaminum, belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine. Methamphetamine is a drug which is used for the treatment of attention deficit disorder with hyperactivity (adhd) and exogenous obesity. Methamphetamine is a very strong basic compound (based on its pKa). Methamphetamine is a potentially toxic compound.
Structure
Data?1676999911
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0015517 (Methamphetamine)

1577
  Mrv0541 02231215342D          

 11 11  0  0  1  0            999 V2000
    3.0791    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  8  1  0  0  0  0
  2  3  1  0  0  0  0
  2  5  1  0  0  0  0
  3  4  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  9 11  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
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3D MOL for HMDB0015517 (Methamphetamine)

HMDB0015517
     RDKit          3D
Methamphetamine
 26 26  0  0  0  0  0  0  0  0999 V2000
   -2.5606   -1.3768   -0.5969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4939   -0.7719    0.1461 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2673    0.5974   -0.1480 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4957    1.3909    0.2326 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0894    1.1810    0.6066 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1664    0.4644    0.2893 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5231   -0.6168    1.0640 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6655   -1.3447    0.8421 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5078   -0.9873   -0.2058 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1507    0.0997   -0.9855 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    0.8245   -0.7433 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9079   -0.6474   -1.3610 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2754   -2.3494   -1.0562 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3944   -1.5781    0.1058 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4814   -1.0131    1.1573 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1375    0.7063   -1.2413 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7893    1.0292    1.2621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3080    2.4812    0.3021 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3582    1.1365   -0.4120 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0611    2.2518    0.3489 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3330    1.1329    1.6767 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8797   -0.9027    1.8777 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546   -2.1938    1.4430 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4147   -1.5404   -0.4063 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8366    0.3521   -1.7995 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7440    1.6743   -1.3823 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  7 22  1  0
  8 23  1  0
  9 24  1  0
 10 25  1  0
 11 26  1  0
M  END
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3D SDF for HMDB0015517 (Methamphetamine)

1577
  Mrv0541 02231215342D          

 11 11  0  0  1  0            999 V2000
    3.0791    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  8  1  0  0  0  0
  2  3  1  0  0  0  0
  2  5  1  0  0  0  0
  3  4  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  9 11  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0015517

> <DATABASE_NAME>
hmdb

> <SMILES>
CN[C@@H](C)CC1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1

> <INCHI_KEY>
MYWUZJCMWCOHBA-VIFPVBQESA-N

> <FORMULA>
C10H15N

> <MOLECULAR_WEIGHT>
149.2328

> <EXACT_MASS>
149.120449485

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_AVERAGE_POLARIZABILITY>
18.039597610039042

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
methyl[(2S)-1-phenylpropan-2-yl]amine

> <ALOGPS_LOGP>
2.23

> <JCHEM_LOGP>
2.2368308753333324

> <ALOGPS_LOGS>
-2.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
10.20988414728296

> <JCHEM_POLAR_SURFACE_AREA>
12.03

> <JCHEM_REFRACTIVITY>
48.47980000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.28e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
meth

> <JCHEM_VEBER_RULE>
1

$$$$
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3D-SDF for HMDB0015517 (Methamphetamine)

HMDB0015517
     RDKit          3D
Methamphetamine
 26 26  0  0  0  0  0  0  0  0999 V2000
   -2.5606   -1.3768   -0.5969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4939   -0.7719    0.1461 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2673    0.5974   -0.1480 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4957    1.3909    0.2326 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0894    1.1810    0.6066 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1664    0.4644    0.2893 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5231   -0.6168    1.0640 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6655   -1.3447    0.8421 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5078   -0.9873   -0.2058 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1507    0.0997   -0.9855 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    0.8245   -0.7433 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9079   -0.6474   -1.3610 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2754   -2.3494   -1.0562 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3944   -1.5781    0.1058 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4814   -1.0131    1.1573 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1375    0.7063   -1.2413 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7893    1.0292    1.2621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3080    2.4812    0.3021 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3582    1.1365   -0.4120 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0611    2.2518    0.3489 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3330    1.1329    1.6767 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8797   -0.9027    1.8777 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546   -2.1938    1.4430 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4147   -1.5404   -0.4063 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8366    0.3521   -1.7995 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7440    1.6743   -1.3823 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  7 22  1  0
  8 23  1  0
  9 24  1  0
 10 25  1  0
 11 26  1  0
M  END
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PDB for HMDB0015517 (Methamphetamine)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 1577                                              
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  N   UNK     0       5.748   3.080   0.000  0.00  0.00           N+0
HETATM    2  C   UNK     0       5.748   1.540   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.414   0.770   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.414  -0.770   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.081   0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.748  -1.540   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.080  -1.540   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.081   3.850   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.748  -3.080   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.080  -3.080   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.414  -3.850   0.000  0.00  0.00           C+0
CONECT    1    2    8                                                       
CONECT    2    1    3    5                                                  
CONECT    3    2    4                                                       
CONECT    4    3    6    7                                                  
CONECT    5    2                                                            
CONECT    6    4    9                                                       
CONECT    7    4   10                                                       
CONECT    8    1                                                            
CONECT    9    6   11                                                       
CONECT   10    7   11                                                       
CONECT   11    9   10                                                       
MASTER        0    0    0    0    0    0    0    0   11    0   22    0
END
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3D PDB for HMDB0015517 (Methamphetamine)

COMPND    HMDB0015517
HETATM    1  C1  UNL     1      -2.561  -1.377  -0.597  1.00  0.00           C  
HETATM    2  N1  UNL     1      -1.494  -0.772   0.146  1.00  0.00           N  
HETATM    3  C2  UNL     1      -1.267   0.597  -0.148  1.00  0.00           C  
HETATM    4  C3  UNL     1      -2.496   1.391   0.233  1.00  0.00           C  
HETATM    5  C4  UNL     1      -0.089   1.181   0.607  1.00  0.00           C  
HETATM    6  C5  UNL     1       1.166   0.464   0.289  1.00  0.00           C  
HETATM    7  C6  UNL     1       1.523  -0.617   1.064  1.00  0.00           C  
HETATM    8  C7  UNL     1       2.666  -1.345   0.842  1.00  0.00           C  
HETATM    9  C8  UNL     1       3.508  -0.987  -0.206  1.00  0.00           C  
HETATM   10  C9  UNL     1       3.151   0.100  -0.985  1.00  0.00           C  
HETATM   11  C10 UNL     1       1.988   0.824  -0.743  1.00  0.00           C  
HETATM   12  H1  UNL     1      -2.908  -0.647  -1.361  1.00  0.00           H  
HETATM   13  H2  UNL     1      -2.275  -2.349  -1.056  1.00  0.00           H  
HETATM   14  H3  UNL     1      -3.394  -1.578   0.106  1.00  0.00           H  
HETATM   15  H4  UNL     1      -1.481  -1.013   1.157  1.00  0.00           H  
HETATM   16  H5  UNL     1      -1.137   0.706  -1.241  1.00  0.00           H  
HETATM   17  H6  UNL     1      -2.789   1.029   1.262  1.00  0.00           H  
HETATM   18  H7  UNL     1      -2.308   2.481   0.302  1.00  0.00           H  
HETATM   19  H8  UNL     1      -3.358   1.137  -0.412  1.00  0.00           H  
HETATM   20  H9  UNL     1       0.061   2.252   0.349  1.00  0.00           H  
HETATM   21  H10 UNL     1      -0.333   1.133   1.677  1.00  0.00           H  
HETATM   22  H11 UNL     1       0.880  -0.903   1.878  1.00  0.00           H  
HETATM   23  H12 UNL     1       2.955  -2.194   1.443  1.00  0.00           H  
HETATM   24  H13 UNL     1       4.415  -1.540  -0.406  1.00  0.00           H  
HETATM   25  H14 UNL     1       3.837   0.352  -1.800  1.00  0.00           H  
HETATM   26  H15 UNL     1       1.744   1.674  -1.382  1.00  0.00           H  
CONECT    1    2   12   13   14
CONECT    2    3   15
CONECT    3    4    5   16
CONECT    4   17   18   19
CONECT    5    6   20   21
CONECT    6    7    7   11
CONECT    7    8   22
CONECT    8    9    9   23
CONECT    9   10   24
CONECT   10   11   11   25
CONECT   11   26
END
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SMILES for HMDB0015517 (Methamphetamine)

CN[C@@H](C)CC1=CC=CC=C1
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INCHI for HMDB0015517 (Methamphetamine)

InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
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View in JSmolView Stereo Labels
Synonyms
ValueSource
(+)-(S)-N-alpha-DimethylphenethylamineChEBI
(AlphaS)-N,alpha-dimethylbenzeneethanamineChEBI
(S)-N,alpha-DimethylbenzeneethanamineChEBI
D-1-Phenyl-2-methylaminopropaneChEBI
D-DeoxyephedrineChEBI
D-DesoxyephedrineChEBI
D-N-MethylamphetamineChEBI
D-PhenylisopropylmethylamineChEBI
DextromethamphetamineChEBI
MetamfetamineChEBI
MetamfetaminumChEBI
MetanfetaminaChEBI
Methyl-beta-phenylisopropylamineChEBI
(+)-(S)-N-a-DimethylphenethylamineGenerator
(+)-(S)-N-Α-dimethylphenethylamineGenerator
(AlphaS)-N,a-dimethylbenzeneethanamineGenerator
(AlphaS)-N,α-dimethylbenzeneethanamineGenerator
(S)-N,a-DimethylbenzeneethanamineGenerator
(S)-N,Α-dimethylbenzeneethanamineGenerator
Methyl-b-phenylisopropylamineGenerator
Methyl-β-phenylisopropylamineGenerator
(+ )-MethylamphetamineHMDB
(+)-(S)-DeoxyephedrineHMDB
(+)-2-(N-Methylamino)-1-phenylpropaneHMDB
(+)-MethamphetamineHMDB
(+)-MethylamphetamineHMDB
(+)-N,alpha-Dimethyl-beta-phenylethylamineHMDB
(+)-N,alpha-DimethylphenethylamineHMDB
(+)-N-MethylamphetamineHMDB
(2S)-N-Methyl-1-phenylpropan-2-amineHMDB
(S)-(+)-DeoxyephedrineHMDB
(S)-(+)-MethamphetamineHMDB
(S)-(+)-N,alpha,DimethylphenethylamineHMDB
(S)-MethamphetamineHMDB
(S)-MethylamphetamineHMDB
(S)-N,alpha-DimethylbenzeneethanoamineHMDB
1-Phenyl-2-methylaminopropaneHMDB
2S-(+)-MethamphetamineHMDB
D-(S)-MethamphetamineHMDB
D-MethamphetamineHMDB
D-MethylamphetamineHMDB
D-N,alpha-DimethylphenethylamineHMDB
Desoxyephedrine hydrochlorideHMDB
IceHMDB
L-MethamphetamineHMDB
MetamphetamineHMDB
MethHMDB
MethylamphetamineHMDB
N-Methyl-1-phenyl-2-propanamineHMDB
N-Methyl-beta-phenylisopropylamineHMDB
N-MethylamphetamineHMDB
S-(+)-MethamphetamineHMDB
Abbott brand OF methamphetamine hydrochlorideHMDB
Hydrochloride, methamphetamineHMDB
MadrineHMDB
DesoxyephedrineHMDB
DesoxynHMDB
Methamphetamine hydrochlorideHMDB
N MethylamphetamineHMDB
DeoxyephedrineHMDB
Langly brand OF methamphetamine hydrochlorideHMDB
MethamphetamineKEGG
Chemical FormulaC10H15N
Average Molecular Weight149.2328
Monoisotopic Molecular Weight149.120449485
IUPAC Namemethyl[(2S)-1-phenylpropan-2-yl]amine
Traditional Namemeth
CAS Registry Number537-46-2
SMILES
CN[C@@H](C)CC1=CC=CC=C1
InChI Identifier
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
InChI KeyMYWUZJCMWCOHBA-VIFPVBQESA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentAmphetamines and derivatives
Alternative Parents
Substituents
  • Amphetamine or derivatives
  • Phenylpropane
  • Aralkylamine
  • Secondary amine
  • Secondary aliphatic amine
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological location
ProcessNot Available
Role
Indirect biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.93 g/LNot Available
LogP2.07HANSCH,C ET AL. (1995)
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.93 g/LALOGPS
logP2.23ALOGPS
logP2.24ChemAxon
logS-2.2ALOGPS
pKa (Strongest Basic)10.21ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area12.03 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity48.48 m³·mol⁻¹ChemAxon
Polarizability18.04 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+133.61931661259
DarkChem[M-H]-131.731661259
DeepCCS[M+H]+135.08730932474
DeepCCS[M-H]-132.16230932474
DeepCCS[M-2H]-168.57930932474
DeepCCS[M+Na]+144.10730932474
AllCCS[M+H]+132.932859911
AllCCS[M+H-H2O]+128.432859911
AllCCS[M+NH4]+137.232859911
AllCCS[M+Na]+138.432859911
AllCCS[M-H]-136.332859911
AllCCS[M+Na-2H]-137.832859911
AllCCS[M+HCOO]-139.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MethamphetamineCN[C@@H](C)CC1=CC=CC=C11604.0Standard polar33892256
MethamphetamineCN[C@@H](C)CC1=CC=CC=C11183.5Standard non polar33892256
MethamphetamineCN[C@@H](C)CC1=CC=CC=C11188.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Methamphetamine,1TMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C1414.4Semi standard non polar33892256
Methamphetamine,1TMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C1398.1Standard non polar33892256
Methamphetamine,1TMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C1627.5Standard polar33892256
Methamphetamine,1TBDMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C(C)(C)C1632.3Semi standard non polar33892256
Methamphetamine,1TBDMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C(C)(C)C1638.4Standard non polar33892256
Methamphetamine,1TBDMS,isomer #1C[C@@H](CC1=CC=CC=C1)N(C)[Si](C)(C)C(C)(C)C1778.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Methamphetamine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4i-9100000000-d5c137de90ac4540f8bb2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Methamphetamine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-0a4i-9000000000-fd0454cafd58d60de7132014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0gb9-2900000000-9f47787fb23e13a87dad2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0udi-0900000000-7337ca7928cea10bffe52017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0udl-5900000000-03d47250c7a980a66e202017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9300000000-d10984417cc7279a776b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-ba626750e38f88879a892017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-3e56ce6f6bf92f4b0a142017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-4095966beeb0165843c92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0udi-0900000000-7337ca7928cea10bffe52017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0udl-5900000000-bb1f4cbf0ac7cca4d6912017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9300000000-6e88a7d0ffb252a513da2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-70ddbc2127d9ecc43ec02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-faa0136ac65ec9065e492017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0006-9000000000-ce6e9f98d322c724f0262017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-ITFT , positive-QTOFsplash10-0gb9-2900000000-753b4591b9e358e01e682017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-QFT , positive-QTOFsplash10-00kf-9800000000-94af1bb67acf7028de892017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-QFT , positive-QTOFsplash10-00kf-9800000000-904b385cb2c1370393d62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-QFT , positive-QTOFsplash10-0006-9200000000-49618d55cba0c2470ba62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-QFT , positive-QTOFsplash10-0006-9000000000-3167ad4af9af7ec206572017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methamphetamine LC-ESI-QFT , positive-QTOFsplash10-0006-9000000000-351c5861a20ce31f40a92017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 10V, Positive-QTOFsplash10-0udi-0900000000-6ca41b91a4dd107137f52016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 20V, Positive-QTOFsplash10-0uxr-3900000000-7fa23fc8e2e96d14abcc2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 40V, Positive-QTOFsplash10-0006-9300000000-104f35aae3c1bcbc78872016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 10V, Negative-QTOFsplash10-0002-0900000000-503d557b64d8fcd09a362016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 20V, Negative-QTOFsplash10-0002-1900000000-d34387a31168c299ab032016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methamphetamine 40V, Negative-QTOFsplash10-0ku6-9400000000-3a9b55d0b53a10725f672016-08-03Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Quadrupole Ion Trap, ESI+, Adduct: [M+H]+)2022-02-11FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Kidney
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01577 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01577 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01577
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDC00042732
Chemspider ID10379
KEGG Compound IDC07164
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMethamphetamine
METLIN IDNot Available
PubChem Compound10836
PDB IDNot Available
ChEBI ID6809
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Bennett BA, Hollingsworth CK, Martin RS, Harp JJ: Methamphetamine-induced alterations in dopamine transporter function. Brain Res. 1998 Jan 26;782(1-2):219-27. [PubMed:9519266 ]
  2. Shaner JW: Caries associated with methamphetamine abuse. J Mich Dent Assoc. 2002 Sep;84(9):42-7. [PubMed:12271905 ]
  3. Schepers RJ, Oyler JM, Joseph RE Jr, Cone EJ, Moolchan ET, Huestis MA: Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin Chem. 2003 Jan;49(1):121-32. [PubMed:12507968 ]
  4. Hasan AA, Ciancio S: Relationship between amphetamine ingestion and gingival enlargement. Pediatr Dent. 2004 Sep-Oct;26(5):396-400. [PubMed:15460293 ]
  5. McGregor C, Srisurapanont M, Jittiwutikarn J, Laobhripatr S, Wongtan T, White JM: The nature, time course and severity of methamphetamine withdrawal. Addiction. 2005 Sep;100(9):1320-9. [PubMed:16128721 ]
  6. Ko BJ, Suh S, Suh YJ, In MK, Kim SH, Kim JH: (1S,2S)-1-Methylamino-1-phenyl-2-chloropropane: Route specific marker impurity of methamphetamine synthesized from ephedrine via chloroephedrine. Forensic Sci Int. 2012 Sep 10;221(1-3):92-7. doi: 10.1016/j.forsciint.2012.04.008. Epub 2012 May 2. [PubMed:22554873 ]

Only showing the first 10 proteins. There are 14 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Amine oxidase [flavin-containing] B
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
References
  1. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
Enzyme Details
2. Amine oxidase [flavin-containing] A
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
References
  1. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
Enzyme Details
3. Cytochrome P450 2D6
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
4. Alpha-2A adrenergic receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48956.3
References
  1. Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. [PubMed:9551769 ]
  2. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
  3. Nishio M, Kanda Y, Mizuno K, Watanabe Y: Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8. [PubMed:12453616 ]
Enzyme Details
5. Alpha-2B adrenergic receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular weight:
49953.1
References
  1. Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. [PubMed:9551769 ]
  2. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
Enzyme Details
6. Synaptic vesicular amine transporter
General function:
Involved in transmembrane transport
Specific function:
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis
Gene Name:
SLC18A2
Uniprot ID:
Q05940
Molecular weight:
55712.1
References
  1. Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP: meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Mar;336(3):940-51. doi: 10.1124/jpet.110.175117. Epub 2010 Dec 21. [PubMed:21177475 ]
  2. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
  3. Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A: Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci. 1995 May;15(5 Pt 2):4102-8. [PubMed:7751968 ]
  4. Yasumoto S, Tamura K, Karasawa J, Hasegawa R, Ikeda K, Yamamoto T, Yamamoto H: Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2. Neurosci Lett. 2009 May 1;454(3):229-32. doi: 10.1016/j.neulet.2009.03.049. Epub 2009 Mar 18. [PubMed:19429089 ]
  5. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. [PubMed:17209801 ]
Enzyme Details
7. Sodium-dependent dopamine transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular weight:
68494.255
References
  1. Escubedo E, Camarasa J, Chipana C, Garcia-Rates S, Pubill D: Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications. Int Rev Neurobiol. 2009;88:121-66. doi: 10.1016/S0074-7742(09)88006-9. [PubMed:19897077 ]
  2. Lott DC, Kim SJ, Cook EH Jr, de Wit H: Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar;30(3):602-9. [PubMed:15602501 ]
  3. Fone KC, Nutt DJ: Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol. 2005 Feb;5(1):87-93. [PubMed:15661631 ]
  4. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. [PubMed:15764732 ]
  5. Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A: Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol. 2005 Jul;68(1):102-9. Epub 2005 Mar 28. [PubMed:15795321 ]
  6. Madras BK, Miller GM, Fischman AJ: The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1397-409. Epub 2005 Jan 5. [PubMed:15950014 ]
  7. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A: Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22. [PubMed:15728379 ]
  8. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. [PubMed:17209801 ]
Enzyme Details
8. Chromaffin granule amine transporter
General function:
Carbohydrate transport and metabolism
Specific function:
Involved in the vesicular transport of biogenic amines
Gene Name:
SLC18A1
Uniprot ID:
P54219
Molecular weight:
56258.0
References
  1. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
  2. Henry JP, Sagne C, Bedet C, Gasnier B: The vesicular monoamine transporter: from chromaffin granule to brain. Neurochem Int. 1998 Mar;32(3):227-46. [PubMed:9587917 ]
  3. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. [PubMed:17209801 ]
Enzyme Details
9. Alpha-2C adrenergic receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular weight:
49521.6
References
  1. Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. [PubMed:9551769 ]
  2. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
Enzyme Details
10. Trace amine-associated receptor 1
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase
Gene Name:
TAAR1
Uniprot ID:
Q96RJ0
Molecular weight:
39091.3
References
  1. Grandy DK: Trace amine-associated receptor 1-Family archetype or iconoclast? Pharmacol Ther. 2007 Dec;116(3):355-90. Epub 2007 Jul 17. [PubMed:17888514 ]
  2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C: Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71. Epub 2001 Jul 17. [PubMed:11459929 ]
  3. Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK: Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther. 2007 Apr;321(1):178-86. Epub 2007 Jan 11. [PubMed:17218486 ]
  4. Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM: Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr;321(1):116-27. Epub 2007 Jan 18. [PubMed:17234900 ]
  5. Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP: The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39. Epub 2006 Dec 21. [PubMed:17212650 ]
  6. Xie Z, Miller GM: Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther. 2007 Apr;321(1):128-36. Epub 2007 Jan 18. [PubMed:17234899 ]
  7. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. [PubMed:15764732 ]

Transporters

Enzyme Details
1. Solute carrier family 22 member 5
General function:
Involved in ion transmembrane transporter activity
Specific function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular weight:
62751.1
References
  1. Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. [PubMed:9618255 ]
  2. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
Enzyme Details
2. Sodium-dependent noradrenaline transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular weight:
69331.42
References
  1. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. [PubMed:17209801 ]
  2. Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. [PubMed:15955613 ]
Enzyme Details
3. Sodium-dependent serotonin transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular weight:
70324.165
References
  1. Numachi Y, Ohara A, Yamashita M, Fukushima S, Kobayashi H, Hata H, Watanabe H, Hall FS, Lesch KP, Murphy DL, Uhl GR, Sora I: Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol. 2007 Oct 31;572(2-3):120-8. Epub 2007 Jun 27. [PubMed:17673199 ]
  2. Tellez R, Rocha L, Castillo C, Meneses A: Autoradiographic study of serotonin transporter during memory formation. Behav Brain Res. 2010 Sep 1;212(1):12-26. doi: 10.1016/j.bbr.2010.03.015. Epub 2010 Mar 11. [PubMed:20226815 ]
  3. Sora I, Li B, Fumushima S, Fukui A, Arime Y, Kasahara Y, Tomita H, Ikeda K: Monoamine transporter as a target molecule for psychostimulants. Int Rev Neurobiol. 2009;85:29-33. doi: 10.1016/S0074-7742(09)85003-4. [PubMed:19607959 ]
Enzyme Details
4. Solute carrier family 22 member 3
General function:
Involved in transmembrane transport
Specific function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular weight:
61279.5
References
  1. Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. [PubMed:9830022 ]

Only showing the first 10 proteins. There are 14 proteins in total.

Show all enzymes and transporters