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Showing metabocard for Gonadorelin (HMDB0014782)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
enzymes (2) Show 2 proteins
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:44 UTC
HMDB IDHMDB0014782
Secondary Accession Numbers
  • HMDB14782
Metabolite Identification
Common NameGonadorelin
DescriptionGonadorelin is only found in individuals that have used or taken this drug. Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
Structure
Data?1582753220
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014782 (Gonadorelin)

644
  Mrv0541 02231214512D          

 85 90  0  0  1  0            999 V2000
   12.8548   -2.6382    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.9727   -2.5226    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   16.8590   -3.2421    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7800   -1.3064    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2703    4.8342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3500    8.2735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8213    4.2201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2179    1.5938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3562    1.2163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8960    2.8883    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   12.4834    3.1249    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.1495   -4.0365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
Download

3D MOL for HMDB0014782 (Gonadorelin)

HMDB0014782
     RDKit          3D
Gonadorelin
160165  0  0  0  0  0  0  0  0999 V2000
   -4.2850   -0.9168    4.2613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2246   -0.9328    2.7168 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0325   -2.1083    2.2738 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7507    0.3952    2.2925 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7796    0.6612    0.8113 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4855    0.6122    0.1926 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8658    1.8168   -0.2284 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6028    2.8778    0.0149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6122    2.0619   -0.8591 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7694    0.9926   -1.1293 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1312    0.1049   -0.1900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3500    0.2650    1.0123 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7611   -0.9382   -0.7088 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1871   -2.3367   -0.7382 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1452   -2.9064    0.5730 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8874   -3.5446    1.2403 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6758   -4.1232    2.4537 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5899   -4.0726    3.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8191   -4.6614    4.2704 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6195   -3.4423    2.3751 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3761   -2.8535    1.1278 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9493   -0.9656    0.1793 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2145   -0.5632   -0.3117 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3203   -0.1616   -1.4811 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3907   -0.6378    0.5673 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.0965    1.0611 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6414   -2.2232    1.8848 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9603    0.4764   -0.3463 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4249    3.6191   -1.6451 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6479    3.5492   -2.9636 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2410    4.2957   -4.0458 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6681    3.9664   -5.3116 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5057    2.8927   -5.5394 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9290    2.1278   -4.4688 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5025    2.4567   -3.1949 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1745   -0.2278   -0.1160 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3969    0.3313    0.2816 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4374    1.5733    0.4637 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.6199   -0.4635    0.4925 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1927   -1.0105   -0.8184 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2693   -1.8477   -1.5845 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0379   -3.4751   -2.4862 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7751   -2.3427   -3.1517 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5086   -1.3546   -2.6205 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6998    0.3888    1.0091 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5813   -0.1250    1.9913 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4416   -1.2759    2.4115 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6697    0.7465    2.5024 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5444    1.2346    1.3704 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9618    0.8941    1.6954 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8920    0.2263    3.0262 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8596   -0.2095    3.7203 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.5312    0.1308    3.4612 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8179   -0.2057    0.1358 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3837   -1.1934   -0.5315 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1392    0.1762    0.3219 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
Download

3D SDF for HMDB0014782 (Gonadorelin)

644
  Mrv0541 02231214512D          

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    9.2542    2.4444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790    0.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3411    1.3737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6397    2.1041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5762    1.1498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    2.1987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0616    2.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4646    6.7970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7349    7.2073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3179    3.3987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4198    2.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6762    2.9548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
HMDB0014782

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CN=CN1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O

> <INCHI_IDENTIFIER>
InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)

> <INCHI_KEY>
XLXSAKCOAKORKW-UHFFFAOYSA-N

> <FORMULA>
C55H75N17O13

> <MOLECULAR_WEIGHT>
1182.2901

> <EXACT_MASS>
1181.573025571

> <JCHEM_ACCEPTOR_COUNT>
17

> <JCHEM_AVERAGE_POLARIZABILITY>
121.19244764987953

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
16

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
N-(1-{2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl}-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl)-2-{2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamide

> <ALOGPS_LOGP>
-0.09

> <JCHEM_LOGP>
-6.31928858807058

> <ALOGPS_LOGS>
-4.30

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
2

> <JCHEM_PKA>
10.627468721377271

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.470686789181995

> <JCHEM_PKA_STRONGEST_BASIC>
11.16040184683256

> <JCHEM_POLAR_SURFACE_AREA>
474.62999999999977

> <JCHEM_REFRACTIVITY>
302.5053000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
31

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.88e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
gonadotropin releasing hormone

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0014782 (Gonadorelin)

HMDB0014782
     RDKit          3D
Gonadorelin
160165  0  0  0  0  0  0  0  0999 V2000
   -4.2850   -0.9168    4.2613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2246   -0.9328    2.7168 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0325   -2.1083    2.2738 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7507    0.3952    2.2925 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7796    0.6612    0.8113 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4855    0.6122    0.1926 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8658    1.8168   -0.2284 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6028    2.8778    0.0149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6122    2.0619   -0.8591 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7694    0.9926   -1.1293 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1312    0.1049   -0.1900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3500    0.2650    1.0123 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7611   -0.9382   -0.7088 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1871   -2.3367   -0.7382 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1452   -2.9064    0.5730 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8874   -3.5446    1.2403 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6758   -4.1232    2.4537 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5899   -4.0726    3.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8191   -4.6614    4.2704 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6195   -3.4423    2.3751 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3761   -2.8535    1.1278 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9493   -0.9656    0.1793 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2145   -0.5632   -0.3117 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3203   -0.1616   -1.4811 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3907   -0.6378    0.5673 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.0965    1.0611 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6414   -2.2232    1.8848 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5637   -0.2410   -0.1695 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8116    0.0953    0.4633 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8207    0.0151    1.7159 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9603    0.4764   -0.3463 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6938    0.7312   -1.7880 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7740    1.8875   -1.9665 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0945    2.6257   -1.0308 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4249    3.6191   -1.6451 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6479    3.5492   -2.9636 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2410    4.2957   -4.0458 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6681    3.9664   -5.3116 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5057    2.8927   -5.5394 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9290    2.1278   -4.4688 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5025    2.4567   -3.1949 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1745   -0.2278   -0.1160 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3969    0.3313    0.2816 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4374    1.5733    0.4637 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.6199   -0.4635    0.4925 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1927   -1.0105   -0.8184 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2693   -1.8477   -1.5845 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9419   -3.1796   -1.5365 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0379   -3.4751   -2.4862 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7751   -2.3427   -3.1517 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5086   -1.3546   -2.6205 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6998    0.3888    1.0091 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5813   -0.1250    1.9913 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4416   -1.2759    2.4115 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6697    0.7465    2.5024 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5444    1.2346    1.3704 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9618    0.8941    1.6954 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8920    0.2263    3.0262 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8596   -0.2095    3.7203 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.5312    0.1308    3.4612 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8179   -0.2057    0.1358 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3837   -1.1934   -0.5315 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1392    0.1762    0.3219 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3998   -0.3642   -0.1046 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0369   -1.1817   -1.4041 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2632   -1.8094   -1.9622 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9130   -2.8426   -1.0438 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.0429   -3.3562   -1.7274 N   0  0  0  0  0  0  0  0  0  0  0  0
  -12.2519   -3.3572   -1.3948 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8076   -2.8252   -0.2056 N   0  0  0  0  0  0  0  0  0  0  0  0
  -13.1733   -3.9825   -2.3170 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2081    0.7526   -0.5585 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5952    1.5588   -1.3698 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5382    1.0121   -0.1965 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.3725    0.3560    0.7558 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8091    0.8369    0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.7004    1.5129   -0.8771 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.3084    2.0823   -0.8194 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.2392    3.3586   -0.0970 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7118    3.4310    1.0338 O   0  0  0  0  0  0  0  0  0  0  0  0
  -11.7820    4.5117   -0.7087 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.7697    5.8293   -0.0962 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.5260    5.7621    1.1835 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.1288    4.5793    1.6517 N   0  0  0  0  0  0  0  0  0  0  0  0
  -12.6284    6.8186    1.8806 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7797   -0.0482    4.6756 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3628   -0.8479    4.5107 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1562   -1.0505    2.4816 H   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
Download

PDB for HMDB0014782 (Gonadorelin)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 644                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      23.996  -4.925   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      26.082  -4.709   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      18.997  -7.341   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      31.470  -6.052   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      16.389  -2.439   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0       6.105   9.024   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0       4.387  15.444   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       7.133   7.878   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       9.740   2.975   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      19.332   2.270   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0      14.739   5.391   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      13.304   1.000   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      23.302   5.833   0.000  0.00  0.00           O+0
HETATM   14  N   UNK     0      24.546  -7.535   0.000  0.00  0.00           N+0
HETATM   15  N   UNK     0      20.982  -5.560   0.000  0.00  0.00           N+0
HETATM   16  N   UNK     0      28.390  -6.047   0.000  0.00  0.00           N+0
HETATM   17  N   UNK     0      18.925  -3.267   0.000  0.00  0.00           N+0
HETATM   18  N   UNK     0      23.110 -11.926   0.000  0.00  0.00           N+0
HETATM   19  N   UNK     0      31.475  -3.385   0.000  0.00  0.00           N+0
HETATM   20  N   UNK     0       5.877  13.140   0.000  0.00  0.00           N+0
HETATM   21  N   UNK     0       8.090  10.805   0.000  0.00  0.00           N+0
HETATM   22  N   UNK     0      17.346   0.489   0.000  0.00  0.00           N+0
HETATM   23  N   UNK     0       9.668   7.049   0.000  0.00  0.00           N+0
HETATM   24  N   UNK     0      11.725   4.756   0.000  0.00  0.00           N+0
HETATM   25  N   UNK     0      15.289   2.782   0.000  0.00  0.00           N+0
HETATM   26  N   UNK     0      23.661 -14.536   0.000  0.00  0.00           N+0
HETATM   27  N   UNK     0      21.125 -13.708   0.000  0.00  0.00           N+0
HETATM   28  N   UNK     0       7.205   1.325   0.000  0.00  0.00           N+0
HETATM   29  N   UNK     0      12.569  11.914   0.000  0.00  0.00           N+0
HETATM   30  N   UNK     0      11.108  13.932   0.000  0.00  0.00           N+0
HETATM   31  C   UNK     0      26.078  -7.376   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      26.702  -8.784   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      25.555  -9.813   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      24.223  -9.041   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      23.517  -6.388   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      22.010  -6.706   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      26.850  -6.044   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      21.532  -8.170   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0      22.560  -9.316   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0      18.446  -4.731   0.000  0.00  0.00           C+0
HETATM   41  C   UNK     0      19.475  -5.877   0.000  0.00  0.00           C+0
HETATM   42  C   UNK     0      16.939  -5.049   0.000  0.00  0.00           C+0
HETATM   43  C   UNK     0      22.082 -10.780   0.000  0.00  0.00           C+0
HETATM   44  C   UNK     0      29.162  -4.714   0.000  0.00  0.00           C+0
HETATM   45  C   UNK     0      16.461  -6.513   0.000  0.00  0.00           C+0
HETATM   46  C   UNK     0      14.954  -6.830   0.000  0.00  0.00           C+0
HETATM   47  C   UNK     0      17.490  -7.659   0.000  0.00  0.00           C+0
HETATM   48  C   UNK     0      30.702  -4.717   0.000  0.00  0.00           C+0
HETATM   49  C   UNK     0      17.896  -2.121   0.000  0.00  0.00           C+0
HETATM   50  C   UNK     0       5.554  11.634   0.000  0.00  0.00           C+0
HETATM   51  C   UNK     0       4.022  11.476   0.000  0.00  0.00           C+0
HETATM   52  C   UNK     0      18.375  -0.657   0.000  0.00  0.00           C+0
HETATM   53  C   UNK     0       3.399  12.884   0.000  0.00  0.00           C+0
HETATM   54  C   UNK     0       9.118   9.659   0.000  0.00  0.00           C+0
HETATM   55  C   UNK     0       9.190   5.585   0.000  0.00  0.00           C+0
HETATM   56  C   UNK     0      22.632 -13.390   0.000  0.00  0.00           C+0
HETATM   57  C   UNK     0       6.583  10.487   0.000  0.00  0.00           C+0
HETATM   58  C   UNK     0       7.683   5.268   0.000  0.00  0.00           C+0
HETATM   59  C   UNK     0       4.545  13.912   0.000  0.00  0.00           C+0
HETATM   60  C   UNK     0      10.625   9.976   0.000  0.00  0.00           C+0
HETATM   61  C   UNK     0       8.640   8.195   0.000  0.00  0.00           C+0
HETATM   62  C   UNK     0       7.205   3.804   0.000  0.00  0.00           C+0
HETATM   63  C   UNK     0      16.796   3.099   0.000  0.00  0.00           C+0
HETATM   64  C   UNK     0      10.219   4.439   0.000  0.00  0.00           C+0
HETATM   65  C   UNK     0      17.825   1.953   0.000  0.00  0.00           C+0
HETATM   66  C   UNK     0       5.747   3.334   0.000  0.00  0.00           C+0
HETATM   67  C   UNK     0      12.754   3.610   0.000  0.00  0.00           C+0
HETATM   68  C   UNK     0      11.104  11.440   0.000  0.00  0.00           C+0
HETATM   69  C   UNK     0      17.275   4.563   0.000  0.00  0.00           C+0
HETATM   70  C   UNK     0       5.747   1.794   0.000  0.00  0.00           C+0
HETATM   71  C   UNK     0       8.103   2.564   0.000  0.00  0.00           C+0
HETATM   72  C   UNK     0      14.261   3.928   0.000  0.00  0.00           C+0
HETATM   73  C   UNK     0      12.276   2.146   0.000  0.00  0.00           C+0
HETATM   74  C   UNK     0       4.414   4.104   0.000  0.00  0.00           C+0
HETATM   75  C   UNK     0      18.782   4.880   0.000  0.00  0.00           C+0
HETATM   76  C   UNK     0       4.414   1.024   0.000  0.00  0.00           C+0
HETATM   77  C   UNK     0      10.201  12.688   0.000  0.00  0.00           C+0
HETATM   78  C   UNK     0       3.080   3.334   0.000  0.00  0.00           C+0
HETATM   79  C   UNK     0       3.080   1.794   0.000  0.00  0.00           C+0
HETATM   80  C   UNK     0      12.572  13.454   0.000  0.00  0.00           C+0
HETATM   81  C   UNK     0      19.260   6.344   0.000  0.00  0.00           C+0
HETATM   82  C   UNK     0      19.810   3.734   0.000  0.00  0.00           C+0
HETATM   83  C   UNK     0      20.767   6.662   0.000  0.00  0.00           C+0
HETATM   84  C   UNK     0      21.317   4.052   0.000  0.00  0.00           C+0
HETATM   85  C   UNK     0      21.796   5.516   0.000  0.00  0.00           C+0
CONECT    1   35                                                            
CONECT    2   37                                                            
CONECT    3   41                                                            
CONECT    4   48                                                            
CONECT    5   49                                                            
CONECT    6   57                                                            
CONECT    7   59                                                            
CONECT    8   61                                                            
CONECT    9   64                                                            
CONECT   10   65                                                            
CONECT   11   72                                                            
CONECT   12   73                                                            
CONECT   13   85                                                            
CONECT   14   31   34   35                                                  
CONECT   15   36   41                                                       
CONECT   16   37   44                                                       
CONECT   17   40   49                                                       
CONECT   18   43   56                                                       
CONECT   19   48                                                            
CONECT   20   50   59                                                       
CONECT   21   54   57                                                       
CONECT   22   52   65                                                       
CONECT   23   55   61                                                       
CONECT   24   64   67                                                       
CONECT   25   63   72                                                       
CONECT   26   56                                                            
CONECT   27   56                                                            
CONECT   28   70   71                                                       
CONECT   29   68   80                                                       
CONECT   30   77   80                                                       
CONECT   31   14   32   37                                                  
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   14   33                                                       
CONECT   35    1   14   36                                                  
CONECT   36   15   35   38                                                  
CONECT   37    2   16   31                                                  
CONECT   38   36   39                                                       
CONECT   39   38   43                                                       
CONECT   40   17   41   42                                                  
CONECT   41    3   15   40                                                  
CONECT   42   40   45                                                       
CONECT   43   18   39                                                       
CONECT   44   16   48                                                       
CONECT   45   42   46   47                                                  
CONECT   46   45                                                            
CONECT   47   45                                                            
CONECT   48    4   19   44                                                  
CONECT   49    5   17   52                                                  
CONECT   50   20   51   57                                                  
CONECT   51   50   53                                                       
CONECT   52   22   49                                                       
CONECT   53   51   59                                                       
CONECT   54   21   60   61                                                  
CONECT   55   23   58   64                                                  
CONECT   56   18   26   27                                                  
CONECT   57    6   21   50                                                  
CONECT   58   55   62                                                       
CONECT   59    7   20   53                                                  
CONECT   60   54   68                                                       
CONECT   61    8   23   54                                                  
CONECT   62   58   66   71                                                  
CONECT   63   25   65   69                                                  
CONECT   64    9   24   55                                                  
CONECT   65   10   22   63                                                  
CONECT   66   62   70   74                                                  
CONECT   67   24   72   73                                                  
CONECT   68   29   60   77                                                  
CONECT   69   63   75                                                       
CONECT   70   28   66   76                                                  
CONECT   71   28   62                                                       
CONECT   72   11   25   67                                                  
CONECT   73   12   67                                                       
CONECT   74   66   78                                                       
CONECT   75   69   81   82                                                  
CONECT   76   70   79                                                       
CONECT   77   30   68                                                       
CONECT   78   74   79                                                       
CONECT   79   76   78                                                       
CONECT   80   29   30                                                       
CONECT   81   75   83                                                       
CONECT   82   75   84                                                       
CONECT   83   81   85                                                       
CONECT   84   82   85                                                       
CONECT   85   13   83   84                                                  
MASTER        0    0    0    0    0    0    0    0   85    0  180    0
END
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3D PDB for HMDB0014782 (Gonadorelin)

COMPND    HMDB0014782
HETATM    1  C1  UNL     1      -4.285  -0.917   4.261  1.00  0.00           C  
HETATM    2  C2  UNL     1      -4.225  -0.933   2.717  1.00  0.00           C  
HETATM    3  C3  UNL     1      -5.032  -2.108   2.274  1.00  0.00           C  
HETATM    4  C4  UNL     1      -4.751   0.395   2.292  1.00  0.00           C  
HETATM    5  C5  UNL     1      -4.780   0.661   0.811  1.00  0.00           C  
HETATM    6  N1  UNL     1      -3.486   0.612   0.193  1.00  0.00           N  
HETATM    7  C6  UNL     1      -2.866   1.817  -0.228  1.00  0.00           C  
HETATM    8  O1  UNL     1      -3.603   2.878   0.015  1.00  0.00           O  
HETATM    9  C7  UNL     1      -1.612   2.062  -0.859  1.00  0.00           C  
HETATM   10  N2  UNL     1      -0.769   0.993  -1.129  1.00  0.00           N  
HETATM   11  C8  UNL     1      -0.131   0.105  -0.190  1.00  0.00           C  
HETATM   12  O2  UNL     1      -0.350   0.265   1.012  1.00  0.00           O  
HETATM   13  C9  UNL     1       0.761  -0.938  -0.709  1.00  0.00           C  
HETATM   14  C10 UNL     1       0.187  -2.337  -0.738  1.00  0.00           C  
HETATM   15  C11 UNL     1      -0.145  -2.906   0.573  1.00  0.00           C  
HETATM   16  C12 UNL     1       0.887  -3.545   1.240  1.00  0.00           C  
HETATM   17  C13 UNL     1       0.676  -4.123   2.454  1.00  0.00           C  
HETATM   18  C14 UNL     1      -0.590  -4.073   3.027  1.00  0.00           C  
HETATM   19  O3  UNL     1      -0.819  -4.661   4.270  1.00  0.00           O  
HETATM   20  C15 UNL     1      -1.619  -3.442   2.375  1.00  0.00           C  
HETATM   21  C16 UNL     1      -1.376  -2.854   1.128  1.00  0.00           C  
HETATM   22  N3  UNL     1       1.949  -0.966   0.179  1.00  0.00           N  
HETATM   23  C17 UNL     1       3.215  -0.563  -0.312  1.00  0.00           C  
HETATM   24  O4  UNL     1       3.320  -0.162  -1.481  1.00  0.00           O  
HETATM   25  C18 UNL     1       4.391  -0.638   0.567  1.00  0.00           C  
HETATM   26  C19 UNL     1       4.547  -2.096   1.061  1.00  0.00           C  
HETATM   27  O5  UNL     1       5.641  -2.223   1.885  1.00  0.00           O  
HETATM   28  N4  UNL     1       5.564  -0.241  -0.169  1.00  0.00           N  
HETATM   29  C20 UNL     1       6.812   0.095   0.463  1.00  0.00           C  
HETATM   30  O6  UNL     1       6.821   0.015   1.716  1.00  0.00           O  
HETATM   31  C21 UNL     1       7.960   0.476  -0.346  1.00  0.00           C  
HETATM   32  C22 UNL     1       7.694   0.731  -1.788  1.00  0.00           C  
HETATM   33  C23 UNL     1       6.774   1.888  -1.966  1.00  0.00           C  
HETATM   34  C24 UNL     1       6.094   2.626  -1.031  1.00  0.00           C  
HETATM   35  N5  UNL     1       5.425   3.619  -1.645  1.00  0.00           N  
HETATM   36  C25 UNL     1       5.648   3.549  -2.964  1.00  0.00           C  
HETATM   37  C26 UNL     1       5.241   4.296  -4.046  1.00  0.00           C  
HETATM   38  C27 UNL     1       5.668   3.966  -5.312  1.00  0.00           C  
HETATM   39  C28 UNL     1       6.506   2.893  -5.539  1.00  0.00           C  
HETATM   40  C29 UNL     1       6.929   2.128  -4.469  1.00  0.00           C  
HETATM   41  C30 UNL     1       6.503   2.457  -3.195  1.00  0.00           C  
HETATM   42  N6  UNL     1       9.174  -0.228  -0.116  1.00  0.00           N  
HETATM   43  C31 UNL     1      10.397   0.331   0.282  1.00  0.00           C  
HETATM   44  O7  UNL     1      10.437   1.573   0.464  1.00  0.00           O  
HETATM   45  C32 UNL     1      11.620  -0.464   0.493  1.00  0.00           C  
HETATM   46  C33 UNL     1      12.193  -1.010  -0.818  1.00  0.00           C  
HETATM   47  C34 UNL     1      11.269  -1.848  -1.585  1.00  0.00           C  
HETATM   48  C35 UNL     1      10.942  -3.180  -1.536  1.00  0.00           C  
HETATM   49  N7  UNL     1      10.038  -3.475  -2.486  1.00  0.00           N  
HETATM   50  C36 UNL     1       9.775  -2.343  -3.152  1.00  0.00           C  
HETATM   51  N8  UNL     1      10.509  -1.355  -2.620  1.00  0.00           N  
HETATM   52  N9  UNL     1      12.700   0.389   1.009  1.00  0.00           N  
HETATM   53  C37 UNL     1      13.581  -0.125   1.991  1.00  0.00           C  
HETATM   54  O8  UNL     1      13.442  -1.276   2.412  1.00  0.00           O  
HETATM   55  C38 UNL     1      14.670   0.746   2.502  1.00  0.00           C  
HETATM   56  C39 UNL     1      15.544   1.235   1.370  1.00  0.00           C  
HETATM   57  C40 UNL     1      16.962   0.894   1.695  1.00  0.00           C  
HETATM   58  C41 UNL     1      16.892   0.226   3.026  1.00  0.00           C  
HETATM   59  O9  UNL     1      17.860  -0.210   3.720  1.00  0.00           O  
HETATM   60  N10 UNL     1      15.531   0.131   3.461  1.00  0.00           N  
HETATM   61  C42 UNL     1      -5.818  -0.206   0.136  1.00  0.00           C  
HETATM   62  O10 UNL     1      -5.384  -1.193  -0.532  1.00  0.00           O  
HETATM   63  N11 UNL     1      -7.139   0.176   0.322  1.00  0.00           N  
HETATM   64  C43 UNL     1      -8.400  -0.364  -0.105  1.00  0.00           C  
HETATM   65  C44 UNL     1      -8.037  -1.182  -1.404  1.00  0.00           C  
HETATM   66  C45 UNL     1      -9.263  -1.809  -1.962  1.00  0.00           C  
HETATM   67  C46 UNL     1      -9.913  -2.843  -1.044  1.00  0.00           C  
HETATM   68  N12 UNL     1     -11.043  -3.356  -1.727  1.00  0.00           N  
HETATM   69  C47 UNL     1     -12.252  -3.357  -1.395  1.00  0.00           C  
HETATM   70  N13 UNL     1     -12.808  -2.825  -0.206  1.00  0.00           N  
HETATM   71  N14 UNL     1     -13.173  -3.983  -2.317  1.00  0.00           N  
HETATM   72  C48 UNL     1      -9.208   0.753  -0.558  1.00  0.00           C  
HETATM   73  O11 UNL     1      -8.595   1.559  -1.370  1.00  0.00           O  
HETATM   74  N15 UNL     1     -10.538   1.012  -0.196  1.00  0.00           N  
HETATM   75  C49 UNL     1     -11.372   0.356   0.756  1.00  0.00           C  
HETATM   76  C50 UNL     1     -12.809   0.837   0.464  1.00  0.00           C  
HETATM   77  C51 UNL     1     -12.700   1.513  -0.877  1.00  0.00           C  
HETATM   78  C52 UNL     1     -11.308   2.082  -0.819  1.00  0.00           C  
HETATM   79  C53 UNL     1     -11.239   3.359  -0.097  1.00  0.00           C  
HETATM   80  O12 UNL     1     -10.712   3.431   1.034  1.00  0.00           O  
HETATM   81  N16 UNL     1     -11.782   4.512  -0.709  1.00  0.00           N  
HETATM   82  C54 UNL     1     -11.770   5.829  -0.096  1.00  0.00           C  
HETATM   83  C55 UNL     1     -12.526   5.762   1.183  1.00  0.00           C  
HETATM   84  N17 UNL     1     -13.129   4.579   1.652  1.00  0.00           N  
HETATM   85  O13 UNL     1     -12.628   6.819   1.881  1.00  0.00           O  
HETATM   86  H1  UNL     1      -3.780  -0.048   4.676  1.00  0.00           H  
HETATM   87  H2  UNL     1      -5.363  -0.848   4.511  1.00  0.00           H  
HETATM   88  H3  UNL     1      -3.921  -1.887   4.673  1.00  0.00           H  
HETATM   89  H4  UNL     1      -3.156  -1.050   2.482  1.00  0.00           H  
HETATM   90  H5  UNL     1      -5.162  -2.793   3.166  1.00  0.00           H  
HETATM   91  H6  UNL     1      -6.060  -1.864   1.980  1.00  0.00           H  
HETATM   92  H7  UNL     1      -4.544  -2.759   1.515  1.00  0.00           H  
HETATM   93  H8  UNL     1      -5.773   0.544   2.708  1.00  0.00           H  
HETATM   94  H9  UNL     1      -4.054   1.165   2.743  1.00  0.00           H  
HETATM   95  H10 UNL     1      -5.186   1.709   0.720  1.00  0.00           H  
HETATM   96  H11 UNL     1      -2.979  -0.275   0.026  1.00  0.00           H  
HETATM   97  H12 UNL     1      -1.038   2.912  -0.310  1.00  0.00           H  
HETATM   98  H13 UNL     1      -1.828   2.627  -1.845  1.00  0.00           H  
HETATM   99  H14 UNL     1      -0.563   0.786  -2.174  1.00  0.00           H  
HETATM  100  H15 UNL     1       1.143  -0.691  -1.712  1.00  0.00           H  
HETATM  101  H16 UNL     1       0.809  -3.025  -1.346  1.00  0.00           H  
HETATM  102  H17 UNL     1      -0.775  -2.244  -1.321  1.00  0.00           H  
HETATM  103  H18 UNL     1       1.862  -3.599   0.792  1.00  0.00           H  
HETATM  104  H19 UNL     1       1.443  -4.635   3.029  1.00  0.00           H  
HETATM  105  H20 UNL     1      -0.072  -5.116   4.760  1.00  0.00           H  
HETATM  106  H21 UNL     1      -2.618  -3.390   2.801  1.00  0.00           H  
HETATM  107  H22 UNL     1      -2.237  -2.383   0.679  1.00  0.00           H  
HETATM  108  H23 UNL     1       1.814  -1.270   1.132  1.00  0.00           H  
HETATM  109  H24 UNL     1       4.331  -0.056   1.485  1.00  0.00           H  
HETATM  110  H25 UNL     1       3.628  -2.317   1.683  1.00  0.00           H  
HETATM  111  H26 UNL     1       4.543  -2.815   0.239  1.00  0.00           H  
HETATM  112  H27 UNL     1       5.398  -2.660   2.751  1.00  0.00           H  
HETATM  113  H28 UNL     1       5.518  -0.198  -1.195  1.00  0.00           H  
HETATM  114  H29 UNL     1       8.185   1.583   0.094  1.00  0.00           H  
HETATM  115  H30 UNL     1       8.640   0.893  -2.370  1.00  0.00           H  
HETATM  116  H31 UNL     1       7.216  -0.155  -2.269  1.00  0.00           H  
HETATM  117  H32 UNL     1       6.098   2.444   0.030  1.00  0.00           H  
HETATM  118  H33 UNL     1       4.809   4.357  -1.208  1.00  0.00           H  
HETATM  119  H34 UNL     1       4.592   5.145  -3.889  1.00  0.00           H  
HETATM  120  H35 UNL     1       5.381   4.522  -6.205  1.00  0.00           H  
HETATM  121  H36 UNL     1       6.859   2.601  -6.520  1.00  0.00           H  
HETATM  122  H37 UNL     1       7.577   1.299  -4.635  1.00  0.00           H  
HETATM  123  H38 UNL     1       9.131  -1.289  -0.249  1.00  0.00           H  
HETATM  124  H39 UNL     1      11.426  -1.307   1.149  1.00  0.00           H  
HETATM  125  H40 UNL     1      13.048  -1.674  -0.507  1.00  0.00           H  
HETATM  126  H41 UNL     1      12.650  -0.185  -1.381  1.00  0.00           H  
HETATM  127  H42 UNL     1      11.350  -3.901  -0.828  1.00  0.00           H  
HETATM  128  H43 UNL     1       9.068  -2.286  -3.981  1.00  0.00           H  
HETATM  129  H44 UNL     1      10.560  -0.367  -2.892  1.00  0.00           H  
HETATM  130  H45 UNL     1      12.816   1.363   0.650  1.00  0.00           H  
HETATM  131  H46 UNL     1      14.217   1.642   3.022  1.00  0.00           H  
HETATM  132  H47 UNL     1      15.210   0.757   0.411  1.00  0.00           H  
HETATM  133  H48 UNL     1      15.447   2.319   1.208  1.00  0.00           H  
HETATM  134  H49 UNL     1      17.376   0.118   0.980  1.00  0.00           H  
HETATM  135  H50 UNL     1      17.620   1.803   1.742  1.00  0.00           H  
HETATM  136  H51 UNL     1      15.195  -0.317   4.343  1.00  0.00           H  
HETATM  137  H52 UNL     1      -7.269   1.073   0.927  1.00  0.00           H  
HETATM  138  H53 UNL     1      -8.803  -1.080   0.561  1.00  0.00           H  
HETATM  139  H54 UNL     1      -7.591  -0.488  -2.095  1.00  0.00           H  
HETATM  140  H55 UNL     1      -7.399  -2.010  -1.036  1.00  0.00           H  
HETATM  141  H56 UNL     1     -10.002  -1.084  -2.358  1.00  0.00           H  
HETATM  142  H57 UNL     1      -8.930  -2.397  -2.876  1.00  0.00           H  
HETATM  143  H58 UNL     1     -10.162  -2.477  -0.059  1.00  0.00           H  
HETATM  144  H59 UNL     1      -9.124  -3.635  -0.876  1.00  0.00           H  
HETATM  145  H60 UNL     1     -12.431  -2.985   0.746  1.00  0.00           H  
HETATM  146  H61 UNL     1     -13.671  -2.228  -0.312  1.00  0.00           H  
HETATM  147  H62 UNL     1     -13.974  -4.494  -1.920  1.00  0.00           H  
HETATM  148  H63 UNL     1     -13.006  -3.897  -3.323  1.00  0.00           H  
HETATM  149  H64 UNL     1     -11.117   0.702   1.805  1.00  0.00           H  
HETATM  150  H65 UNL     1     -11.383  -0.722   0.758  1.00  0.00           H  
HETATM  151  H66 UNL     1     -13.517   0.013   0.493  1.00  0.00           H  
HETATM  152  H67 UNL     1     -13.077   1.628   1.214  1.00  0.00           H  
HETATM  153  H68 UNL     1     -13.485   2.281  -1.039  1.00  0.00           H  
HETATM  154  H69 UNL     1     -12.703   0.740  -1.684  1.00  0.00           H  
HETATM  155  H70 UNL     1     -10.952   2.220  -1.882  1.00  0.00           H  
HETATM  156  H71 UNL     1     -12.227   4.420  -1.668  1.00  0.00           H  
HETATM  157  H72 UNL     1     -12.317   6.569  -0.743  1.00  0.00           H  
HETATM  158  H73 UNL     1     -10.728   6.154   0.058  1.00  0.00           H  
HETATM  159  H74 UNL     1     -13.167   4.301   2.647  1.00  0.00           H  
HETATM  160  H75 UNL     1     -13.579   3.936   0.952  1.00  0.00           H  
CONECT    1    2   86   87   88
CONECT    2    3    4   89
CONECT    3   90   91   92
CONECT    4    5   93   94
CONECT    5    6   61   95
CONECT    6    7   96
CONECT    7    8    8    9
CONECT    9   10   97   98
CONECT   10   11   99
CONECT   11   12   12   13
CONECT   13   14   22  100
CONECT   14   15  101  102
CONECT   15   16   16   21
CONECT   16   17  103
CONECT   17   18   18  104
CONECT   18   19   20
CONECT   19  105
CONECT   20   21   21  106
CONECT   21  107
CONECT   22   23  108
CONECT   23   24   24   25
CONECT   25   26   28  109
CONECT   26   27  110  111
CONECT   27  112
CONECT   28   29  113
CONECT   29   30   30   31
CONECT   31   32   42  114
CONECT   32   33  115  116
CONECT   33   34   34   41
CONECT   34   35  117
CONECT   35   36  118
CONECT   36   37   37   41
CONECT   37   38  119
CONECT   38   39   39  120
CONECT   39   40  121
CONECT   40   41   41  122
CONECT   42   43  123
CONECT   43   44   44   45
CONECT   45   46   52  124
CONECT   46   47  125  126
CONECT   47   48   48   51
CONECT   48   49  127
CONECT   49   50   50
CONECT   50   51  128
CONECT   51  129
CONECT   52   53  130
CONECT   53   54   54   55
CONECT   55   56   60  131
CONECT   56   57  132  133
CONECT   57   58  134  135
CONECT   58   59   59   60
CONECT   60  136
CONECT   61   62   62   63
CONECT   63   64  137
CONECT   64   65   72  138
CONECT   65   66  139  140
CONECT   66   67  141  142
CONECT   67   68  143  144
CONECT   68   69   69
CONECT   69   70   71
CONECT   70  145  146
CONECT   71  147  148
CONECT   72   73   73   74
CONECT   74   75   78
CONECT   75   76  149  150
CONECT   76   77  151  152
CONECT   77   78  153  154
CONECT   78   79  155
CONECT   79   80   80   81
CONECT   81   82  156
CONECT   82   83  157  158
CONECT   83   84   85   85
CONECT   84  159  160
END
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SMILES for HMDB0014782 (Gonadorelin)

CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CN=CN1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
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INCHI for HMDB0014782 (Gonadorelin)

InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
Gonadoliberin IKegg
GNRH-IKegg
FertagylKegg
CystorelinHMDB
GonadoliberinHMDB
KryptocurHMDB
Luteinizing hormone-releasing hormoneHMDB
FSH Releasing hormoneHMDB
FSH-Releasing hormoneHMDB
FactrelHMDB
Gonadorelin hydrochlorideHMDB
lH-Releasing hormoneHMDB
Gonadotropin releasing hormoneHMDB
LHRHHMDB
Luteinizing hormone releasing hormoneHMDB
lH-FSH Releasing hormoneHMDB
LHFSHRHHMDB
GN-RHHMDB
Gonadotropin-releasing hormoneHMDB
lH FSH Releasing hormoneHMDB
lH Releasing hormoneHMDB
LuliberinHMDB
Releasing hormone, LHFSHHMDB
GNRHHMDB
lH-RHHMDB
Gonadorelin acetateHMDB
LFRHHMDB
LHFSH Releasing hormoneHMDB
DirigestranHMDB
GonadorelinKEGG
Chemical FormulaC55H75N17O13
Average Molecular Weight1182.2901
Monoisotopic Molecular Weight1181.573025571
IUPAC NameN-(1-{2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl}-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl)-2-{2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamide
Traditional Namegonadotropin releasing hormone
CAS Registry Number6918-09-8
SMILES
CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CN=CN1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
InChI Identifier
InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
InChI KeyXLXSAKCOAKORKW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative Parents
Substituents
  • Polypeptide
  • Alpha peptide
  • Tyrosine or derivatives
  • Phenylalanine or derivatives
  • Histidine or derivatives
  • Leucine or derivatives
  • N-acyl-alpha amino acid or derivatives
  • Proline or derivatives
  • Triptan
  • Alpha-amino acid amide
  • Serine or derivatives
  • N-substituted-alpha-amino acid
  • Alpha-amino acid or derivatives
  • Amphetamine or derivatives
  • 3-alkylindole
  • Indole
  • Indole or derivatives
  • N-acylpyrrolidine
  • Pyrrolidine carboxylic acid or derivatives
  • Pyrrolidine-2-carboxamide
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Monocyclic benzene moiety
  • Fatty amide
  • N-acyl-amine
  • Fatty acyl
  • Benzenoid
  • Pyrrolidone
  • 2-pyrrolidone
  • Substituted pyrrole
  • Imidazole
  • Heteroaromatic compound
  • Pyrrolidine
  • Azole
  • Tertiary carboxylic acid amide
  • Pyrrole
  • Guanidine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Primary carboxylic acid amide
  • Lactam
  • Azacycle
  • Carboxylic acid derivative
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Carboximidamide
  • Propargyl-type 1,3-dipolar organic compound
  • Primary alcohol
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Organic oxygen compound
  • Organopnictogen compound
  • Organonitrogen compound
  • Alcohol
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • Gonadotropin-releasing hormone [KO:K05252] (C07607 )
Ontology
Physiological effectNot Available
Disposition
Biological location
ProcessNot Available
RoleNot Available
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.059 g/LNot Available
LogP-3.6Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.059 g/LALOGPS
logP-0.09ALOGPS
logP-6.3ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)9.47ChemAxon
pKa (Strongest Basic)11.16ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count16ChemAxon
Polar Surface Area474.63 ŲChemAxon
Rotatable Bond Count31ChemAxon
Refractivity302.51 m³·mol⁻¹ChemAxon
Polarizability121.19 ųChemAxon
Number of Rings6ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-369.79830932474
DeepCCS[M+Na]+343.62830932474
AllCCS[M+H]+324.232859911
AllCCS[M+H-H2O]+325.132859911
AllCCS[M+NH4]+323.332859911
AllCCS[M+Na]+323.032859911
AllCCS[M-H]-309.132859911
AllCCS[M+Na-2H]-314.432859911
AllCCS[M+HCOO]-320.132859911

Predicted Kovats Retention Indices

Not Available
Spectra

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 10V, Positive-QTOFsplash10-022a-9612402201-7dff9b7217a0eacedfb22016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 20V, Positive-QTOFsplash10-00di-9211300000-050a8099fd2f78a969602016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 40V, Positive-QTOFsplash10-00e9-9010100000-8680e82fb261a184e63e2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 10V, Negative-QTOFsplash10-08gi-2900100000-4512eaf4c4ccb20db2882016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 20V, Negative-QTOFsplash10-0c00-4900001000-7d38c37ce1a213415f702016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 40V, Negative-QTOFsplash10-002f-9101002210-ee45e1d0424df22bb4812016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 10V, Positive-QTOFsplash10-06sc-0601903210-931f1842aade74dcf6052021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 20V, Positive-QTOFsplash10-01ox-1420912010-f255f32c7079119589612021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 40V, Positive-QTOFsplash10-0a4i-0720912000-7a2d79ca06bf9d504e8d2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 10V, Negative-QTOFsplash10-001l-3901310000-81db4811a52fc0c2a20f2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 20V, Negative-QTOFsplash10-0c0c-8905528210-305e33d41cdb03e5ef1b2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gonadorelin 40V, Negative-QTOFsplash10-007o-4910102210-6bd6f8d9e9a35a1f85952021-10-11Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00644 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00644 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00644
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID33562
KEGG Compound IDC07607
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGonadotropin-releasing hormone
METLIN IDNot Available
PubChem Compound36523
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22. [PubMed:16373418 ]
  2. Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18. [PubMed:16621281 ]

Enzymes

Enzyme Details
1. Gonadotropin-releasing hormone receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling
Gene Name:
GNRHR
Uniprot ID:
P30968
Molecular weight:
37730.4
References
  1. Lu ZL, Gallagher R, Sellar R, Coetsee M, Millar RP: Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations. J Biol Chem. 2005 Aug 19;280(33):29796-803. Epub 2005 Jun 20. [PubMed:15967801 ]
  2. Moles G, Carrillo M, Mananos E, Mylonas CC, Zanuy S: Temporal profile of brain and pituitary GnRHs, GnRH-R and gonadotropin mRNA expression and content during early development in European sea bass (Dicentrarchus labrax L.). Gen Comp Endocrinol. 2007 Jan 1;150(1):75-86. Epub 2006 Sep 8. [PubMed:16962597 ]
  3. Mamputha S, Lu ZL, Roeske RW, Millar RP, Katz AA, Flanagan CA: Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor. Mol Endocrinol. 2007 Jan;21(1):281-92. Epub 2006 Sep 14. [PubMed:16973761 ]
  4. Lee PA, Houk CP: Gonadotropin-releasing hormone analog therapy for central precocious puberty and other childhood disorders affecting growth and puberty. Treat Endocrinol. 2006;5(5):287-96. [PubMed:17002488 ]
  5. Bliss SP, Navratil AM, Breed M, Skinner DC, Clay CM, Roberson MS: Signaling complexes associated with the type I gonadotropin-releasing hormone (GnRH) receptor: colocalization of extracellularly regulated kinase 2 and GnRH receptor within membrane rafts. Mol Endocrinol. 2007 Feb;21(2):538-49. Epub 2006 Oct 26. [PubMed:17068198 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Enzyme Details
2. Putative gonadotropin-releasing hormone II receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (Potential)
Gene Name:
GNRHR2
Uniprot ID:
Q96P88
Molecular weight:
19031.1
References
  1. Morgan K, Sellar R, Pawson AJ, Lu ZL, Millar RP: Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. Endocrinology. 2006 Nov;147(11):5041-51. Epub 2006 Aug 17. [PubMed:16916952 ]
  2. Mamputha S, Lu ZL, Roeske RW, Millar RP, Katz AA, Flanagan CA: Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor. Mol Endocrinol. 2007 Jan;21(1):281-92. Epub 2006 Sep 14. [PubMed:16973761 ]
  3. Montagnani Marelli M, Moretti RM, Januszkiewicz-Caulier J, Motta M, Limonta P: Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients? Curr Cancer Drug Targets. 2006 May;6(3):257-69. [PubMed:16712461 ]
  4. Li JH, Choe H, Wang AF, Maiti K, Wang C, Salam A, Chun SY, Lee WK, Kim K, Kwon HB, Seong JY: Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II. Mol Pharmacol. 2005 Apr;67(4):1099-110. Epub 2005 Jan 5. [PubMed:15635044 ]
  5. Silver MR, Sower SA: Functional characterization and kinetic studies of an ancestral lamprey GnRH-III selective type II GnRH receptor from the sea lamprey, Petromyzon marinus. J Mol Endocrinol. 2006 Jun;36(3):601-10. [PubMed:16720727 ]