| Record Information |
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| Version | 5.0 |
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| Status | Detected but not Quantified |
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| Creation Date | 2005-11-16 15:48:42 UTC |
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| Update Date | 2022-03-07 02:49:24 UTC |
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| HMDB ID | HMDB0004974 |
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| Secondary Accession Numbers | |
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| Metabolite Identification |
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| Common Name | GlcCer(d18:1/22:0) |
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| Description | GlcCer(d18:1/22:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GL1a carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues.Cerebrosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Cerebrosides have a single sugar group linked to ceramide. The most common are galactocerebrosides (containing galactose), the least common are glucocerebrosides (containing glucose). Galactocerebrosides are found predominantly in neuronal cell membranes. In contrast glucocerebrosides are not normally found in membranes. Instead, they are typically intermediates in the synthesis or degradation of more complex glycosphingolipids. Galactocerebrosides are synthesized from ceramide and UDP-galactose. Excess lysosomal accumulation of glucocerebrosides is found in Gaucher disease. |
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| Structure | CCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC InChI=1S/C46H89NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-24-26-28-30-32-34-36-42(50)47-39(38-54-46-45(53)44(52)43(51)41(37-48)55-46)40(49)35-33-31-29-27-25-23-16-14-12-10-8-6-4-2/h33,35,39-41,43-46,48-49,51-53H,3-32,34,36-38H2,1-2H3,(H,47,50)/b35-33+/t39-,40+,41+,43+,44-,45+,46+/m0/s1 |
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| Synonyms | | Value | Source |
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| beta-D-Glucopyranosyl-N-(docosanoyl)sphingosine | ChEBI | | beta-D-Glucosyl-N-(behenoyl)sphingosine | ChEBI | | beta-D-Glucosyl-N-docosanoylsphingosine | ChEBI | | beta-GlcCer | ChEBI | | beta-Glucosylceramide | ChEBI | | C22 GlcCer | ChEBI | | CMH | ChEBI | | GlcCer(D18:1/22:0) | ChEBI | | N-(Docosanoyl)-1-beta-glucosyl-sphing-4-enine | ChEBI | | b-D-Glucopyranosyl-N-(docosanoyl)sphingosine | Generator | | Β-D-glucopyranosyl-N-(docosanoyl)sphingosine | Generator | | b-D-Glucosyl-N-(behenoyl)sphingosine | Generator | | Β-D-glucosyl-N-(behenoyl)sphingosine | Generator | | b-D-Glucosyl-N-docosanoylsphingosine | Generator | | Β-D-glucosyl-N-docosanoylsphingosine | Generator | | b-GlcCer | Generator | | Β-glccer | Generator | | b-Glucosylceramide | Generator | | Β-glucosylceramide | Generator | | N-(Docosanoyl)-1-b-glucosyl-sphing-4-enine | Generator | | N-(Docosanoyl)-1-β-glucosyl-sphing-4-enine | Generator | | b-D-Glucosyl-N-(docosanoyl)sphingosine | HMDB | | Β-D-glucosyl-N-(docosanoyl)sphingosine | HMDB | | 1-O-b-D-Glucopyranosyl-ceramide | HMDB | | 1-O-beta-delta-Glucopyranosyl-ceramide | HMDB | | Ganglioside GL1a | HMDB | | Gaucher cerebroside | HMDB | | GLC-beta1->1'cer | HMDB | | GlcCeramide | HMDB | | Glucocerebroside | HMDB | | Glucosylceramide | HMDB | | Glucosylceramide (D18:1/22:0) | ChEBI |
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| Chemical Formula | C46H89NO8 |
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| Average Molecular Weight | 784.2008 |
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| Monoisotopic Molecular Weight | 783.658818829 |
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| IUPAC Name | N-[(2S,3R,4E)-3-hydroxy-1-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]docosanamide |
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| Traditional Name | CMH |
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| CAS Registry Number | Not Available |
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| SMILES | CCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC |
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| InChI Identifier | InChI=1S/C46H89NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-24-26-28-30-32-34-36-42(50)47-39(38-54-46-45(53)44(52)43(51)41(37-48)55-46)40(49)35-33-31-29-27-25-23-16-14-12-10-8-6-4-2/h33,35,39-41,43-46,48-49,51-53H,3-32,34,36-38H2,1-2H3,(H,47,50)/b35-33+/t39-,40+,41+,43+,44-,45+,46+/m0/s1 |
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| InChI Key | YIGARKIIFOHVPF-CNUVFPMCSA-N |
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| Chemical Taxonomy |
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| Description | Belongs to the class of organic compounds known as glycosyl-n-acylsphingosines. Glycosyl-N-acylsphingosines are compounds containing a sphingosine linked to a simple glucosyl moiety. |
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| Kingdom | Organic compounds |
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| Super Class | Lipids and lipid-like molecules |
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| Class | Sphingolipids |
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| Sub Class | Glycosphingolipids |
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| Direct Parent | Glycosyl-N-acylsphingosines |
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| Alternative Parents | |
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| Substituents | - Glycosyl-n-acylsphingosine
- Fatty acyl glycoside
- Fatty acyl glycoside of mono- or disaccharide
- Alkyl glycoside
- Hexose monosaccharide
- Glycosyl compound
- O-glycosyl compound
- Fatty amide
- Fatty acyl
- Monosaccharide
- N-acyl-amine
- Oxane
- Carboxamide group
- Secondary carboxylic acid amide
- Secondary alcohol
- Acetal
- Carboxylic acid derivative
- Oxacycle
- Organoheterocyclic compound
- Polyol
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Alcohol
- Organic oxygen compound
- Organic nitrogen compound
- Primary alcohol
- Carbonyl group
- Organooxygen compound
- Organonitrogen compound
- Aliphatic heteromonocyclic compound
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| Molecular Framework | Aliphatic heteromonocyclic compounds |
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| External Descriptors | |
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| Ontology |
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| Physiological effect | |
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| Disposition | |
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| Process | |
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| Role | |
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| Physical Properties |
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| State | Solid |
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| Experimental Molecular Properties | | Property | Value | Reference |
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| Melting Point | Not Available | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | 0 | Not Available | | LogP | Not Available | Not Available |
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| Experimental Chromatographic Properties | Not Available |
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| Predicted Molecular Properties | |
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| Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesDerivatized| Derivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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| GlcCer(d18:1/22:0),1TMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5780.2 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5425.2 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7173.5 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5790.6 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5433.2 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7067.1 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5777.3 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5422.5 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7059.2 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5769.1 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5429.2 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7101.7 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5883.2 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5311.6 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7041.5 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C | 5749.8 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C | 5402.4 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C | 7146.8 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5995.5 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5536.9 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #1 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7130.3 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5965.5 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5555.1 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #2 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7034.7 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5940.0 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5539.2 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #3 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7029.9 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C(C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5948.2 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C(C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5546.3 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #4 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C(C)(C)C)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7063.8 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 6071.9 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 5421.2 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #5 | CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCCCCCCCCCC | 7003.7 | Standard polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C | 5934.6 | Semi standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C | 5487.6 | Standard non polar | 33892256 | | GlcCer(d18:1/22:0),1TBDMS,isomer #6 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)N(C(=O)CCCCCCCCCCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C | 7090.5 | Standard polar | 33892256 |
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