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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (14) Show 14 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2023-02-21 17:15:44 UTC

HMDB ID

HMDB0001473

Secondary Accession Numbers

HMDB0011735
HMDB01473
HMDB11735

Metabolite Identification

Common Name

Dihydroxyacetone phosphate

Description

Dihydroxyacetone phosphate, also known as dihydroxy-acetone-p or 3-hydroxy-2-oxopropyl phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. Dihydroxyacetone phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Click on genes, proteins and metabolites below to link to respective articles. It is rapidly and reversibly isomerised to glyceraldehyde 3-phosphate. Dihydroxyacetone phosphate exists in all living species, ranging from bacteria to humans. Within humans, dihydroxyacetone phosphate participates in a number of enzymatic reactions. In particular, ubiquinol-8 and dihydroxyacetone phosphate can be biosynthesized from coenzyme Q10 and glycerol 3-phosphate through the action of the enzyme glycerol-3-phosphate dehydrogenase, mitochondrial. In addition, dihydroxyacetone phosphate can be converted into glycerol 3-phosphate; which is catalyzed by the enzyme glycerol-3-phosphate dehydrogenase [nad(+)], cytoplasmic. Enzyme 5.3.1.1 at KEGG Pathway Database. In humans, dihydroxyacetone phosphate is involved in the metabolic disorder called the mitochondrial electron transport chain pathway. Outside of the human body, Dihydroxyacetone phosphate has been detected, but not quantified in, several different foods, such as cardamoms, dates, red beetroots, oil-seed camellia, and kai-lans. This could make dihydroxyacetone phosphate a potential biomarker for the consumption of these foods. Dihydroxyacetone phosphate is a potentially toxic compound. DHAP is a precursor to 2-oxopropanal. Dihydroxyacetone phosphate, with regard to humans, has been found to be associated with several diseases such as lewy body disease, frontotemporal dementia, and alzheimer's disease; dihydroxyacetone phosphate has also been linked to the inborn metabolic disorder transaldolase deficiency. In the Calvin cycle, DHAP is one of the products of the sixfold reduction of 1,3-bisphosphoglycerate by NADPH. Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH2C(O)CH2OPO32-.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
1,3-Dihydroxy-2-propanone monodihydrogen phosphate	ChEBI
1,3-Dihydroxy-2-propanone phosphate	ChEBI
1,3-Dihydroxyacetone 1-phosphate	ChEBI
1-Hydroxy-3-(phosphonooxy)-2-propanone	ChEBI
1-Hydroxy-3-(phosphonooxy)acetone	ChEBI
3-Hydroxy-2-oxopropyl phosphate	ChEBI
DHAP	ChEBI
Dihydroxyacetone monophosphate	ChEBI
Glycerone monophosphate	ChEBI
Glycerone phosphate	ChEBI
1,3-Dihydroxy-2-propanone monodihydrogen phosphoric acid	Generator
1,3-Dihydroxy-2-propanone phosphoric acid	Generator
1,3-Dihydroxyacetone 1-phosphoric acid	Generator
3-Hydroxy-2-oxopropyl phosphoric acid	Generator
Dihydroxyacetone monophosphoric acid	Generator
Glycerone monophosphoric acid	Generator
Glycerone phosphoric acid	Generator
Dihydroxyacetone phosphoric acid	Generator
1,3-Dihydroxy-2-propanone mono(dihydrogen phosphate)	HMDB
Di-OH-acetone-p	HMDB
Dihydroxy-acetone-p	HMDB
Dihydroxy-acetone-phosphate	HMDB
Dihydroxyacetone 3-phosphate	HMDB
Dihydroxyacetone-p	HMDB
Dihydroxyacetone-phosphate	HMDB
Glycerone-phosphate	HMDB
Phosphoric acid ester with 1,3-dihydroxy-2-propanone	HMDB
3-Phosphate, dihydroxyacetone	HMDB
Phosphate, dihydroxyacetone	HMDB
Dihydroxyacetone 3 phosphate	HMDB

Chemical Formula

C₃H₇O₆P

Average Molecular Weight

170.0578

Monoisotopic Molecular Weight

169.998024468

IUPAC Name

(3-hydroxy-2-oxopropoxy)phosphonic acid

Traditional Name

dihydroxyacetone-phosphate

CAS Registry Number

57-04-5

SMILES

OCC(=O)COP(O)(O)=O

InChI Identifier

InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)

InChI Key

GNGACRATGGDKBX-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Monosaccharide phosphates

Alternative Parents

Substituents

Glycerone phosphate
Monosaccharide phosphate
Monoalkyl phosphate
Alkyl phosphate
Glycerone or derivatives
Phosphoric acid ester
Organic phosphoric acid derivative
Alpha-hydroxy ketone
Ketone
Organic oxide
Hydrocarbon derivative
Primary alcohol
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

glycerone phosphates (CHEBI:16108 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	21.9 g/L	ALOGPS
logP	-1.5	ALOGPS
logP	-1.7	ChemAxon
logS	-0.89	ALOGPS
pKa (Strongest Acidic)	1.19	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	104.06 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	30.47 m³·mol⁻¹	ChemAxon
Polarizability	12.64 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	136.308	31661259
DarkChem	[M-H]-	129.853	31661259
AllCCS	[M+H]+	136.39	32859911
AllCCS	[M-H]-	128.459	32859911
DeepCCS	[M+H]+	123.915	30932474
DeepCCS	[M-H]-	120.755	30932474
DeepCCS	[M-2H]-	157.822	30932474
DeepCCS	[M+Na]+	132.669	30932474
AllCCS	[M+H]+	136.4	32859911
AllCCS	[M+H-H2O]+	132.5	32859911
AllCCS	[M+NH4]+	140.0	32859911
AllCCS	[M+Na]+	141.1	32859911
AllCCS	[M-H]-	128.5	32859911
AllCCS	[M+Na-2H]-	130.7	32859911
AllCCS	[M+HCOO]-	133.2	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Dihydroxyacetone phosphate	OCC(=O)COP(O)(O)=O	2663.5	Standard polar	33892256
Dihydroxyacetone phosphate	OCC(=O)COP(O)(O)=O	1394.3	Standard non polar	33892256
Dihydroxyacetone phosphate	OCC(=O)COP(O)(O)=O	1541.7	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Dihydroxyacetone phosphate,1TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O)O	1596.3	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TMS,isomer #2	C[Si](C)(C)OP(=O)(O)OCC(=O)CO	1600.3	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TMS,isomer #3	C[Si](C)(C)OC(=COP(=O)(O)O)CO	1651.5	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TMS,isomer #4	C[Si](C)(C)OC(=CO)COP(=O)(O)O	1668.5	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C	1694.9	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C	1611.0	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C	2082.5	Standard polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C	1688.3	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C	1705.8	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C	2369.6	Standard polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C	1751.8	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C	1715.5	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C	2483.5	Standard polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #4	C[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C	1655.8	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #4	C[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C	1597.3	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #4	C[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C	1897.8	Standard polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #5	C[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C	1720.1	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #5	C[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C	1677.4	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #5	C[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C	2233.0	Standard polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #6	C[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C)CO	1700.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #6	C[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C)CO	1670.7	Standard non polar	33892256
Dihydroxyacetone phosphate,2TMS,isomer #6	C[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C)CO	2220.3	Standard polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1753.6	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1676.1	Standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #1	C[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1779.4	Standard polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	1762.1	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	1706.1	Standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #2	C[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	1982.0	Standard polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	1792.8	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	1686.2	Standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #3	C[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C)O[Si](C)(C)C	2059.2	Standard polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #4	C[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1757.3	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #4	C[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1756.4	Standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #4	C[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1890.1	Standard polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #5	C[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)CO	1739.1	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #5	C[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)CO	1724.4	Standard non polar	33892256
Dihydroxyacetone phosphate,3TMS,isomer #5	C[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)CO	1879.4	Standard polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #1	C[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1810.6	Semi standard non polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #1	C[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1758.4	Standard non polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #1	C[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1761.0	Standard polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #2	C[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1833.6	Semi standard non polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #2	C[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1740.3	Standard non polar	33892256
Dihydroxyacetone phosphate,4TMS,isomer #2	C[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	1843.8	Standard polar	33892256
Dihydroxyacetone phosphate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O)O	1843.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OP(=O)(O)OCC(=O)CO	1852.0	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O)O)CO	1905.0	Semi standard non polar	33892256
Dihydroxyacetone phosphate,1TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O)O	1888.1	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2109.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2052.8	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2316.7	Standard polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2161.1	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2093.4	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2539.7	Standard polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2150.4	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2132.4	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O)O[Si](C)(C)C(C)(C)C	2634.7	Standard polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C(C)(C)C	2101.4	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C(C)(C)C	2021.1	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OP(=O)(OCC(=O)CO)O[Si](C)(C)C(C)(C)C	2137.5	Standard polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2156.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2114.6	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O)O[Si](C)(C)C(C)(C)C	2402.7	Standard polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)CO	2170.6	Semi standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)CO	2078.6	Standard non polar	33892256
Dihydroxyacetone phosphate,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)CO	2395.1	Standard polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2356.5	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2255.6	Standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=O)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2142.5	Standard polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2376.9	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2265.8	Standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2300.8	Standard polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2390.6	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2274.9	Standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2329.7	Standard polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2373.9	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2317.1	Standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=CO)COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2213.3	Standard polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)CO	2360.0	Semi standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)CO	2255.4	Standard non polar	33892256
Dihydroxyacetone phosphate,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)OC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)CO	2205.0	Standard polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2564.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2406.8	Standard non polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OCC(=COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2202.9	Standard polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2592.2	Semi standard non polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2402.3	Standard non polar	33892256
Dihydroxyacetone phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC=C(COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2243.6	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental GC-MS	GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (1 MEOX; 3 TMS)	splash10-0uy4-3954100000-ab5b096e0eac9831cf42	2014-06-16	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (1 MEOX; 3 TMS)	splash10-0g0m-3964100000-cd938c4cea382029ce88	2014-06-16	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (Non-derivatized)	splash10-0uy4-3954100000-ab5b096e0eac9831cf42	2017-09-12	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (Non-derivatized)	splash10-0g0m-3964100000-cd938c4cea382029ce88	2017-09-12	HMDB team, MONA, MassBank	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (Non-derivatized) - 70eV, Positive	splash10-01ot-9400000000-a02e9df63512a60b9324	2016-09-22	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (1 TMS) - 70eV, Positive	splash10-0002-9200000000-79dfc0ac375f4d056dc9	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Dihydroxyacetone phosphate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-QQ , negative-QTOF	splash10-00kb-9600000000-050f206e1fed5aaa8c1f	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-QQ , negative-QTOF	splash10-0002-9100000000-c7eb3c008e10f8e15386	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-QQ , negative-QTOF	splash10-004i-9000000000-0f8d50d1d029df4e6c43	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-QQ , negative-QTOF	splash10-004i-9000000000-7c2d8125a273e3fae4f6	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-QQ , negative-QTOF	splash10-004i-9000000000-517dcdb0a35f00b4b491	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate LC-ESI-ITFT , negative-QTOF	splash10-0002-9000000000-b8d3aeb9415528f3d035	2017-09-14	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate n/a 11V, positive-QTOF	splash10-0udi-2900000000-6091e72aad27af4c7971	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Dihydroxyacetone phosphate n/a 11V, positive-QTOF	splash10-00fr-0900000000-b948afb7a993bfbaf1df	2020-07-22	HMDB team, MONA	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Positive-QTOF	splash10-00di-7900000000-fec8dd084ee59efa2286	2015-04-24	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Positive-QTOF	splash10-0kmi-9800000000-beb639c3fffc815897cc	2015-04-24	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 40V, Positive-QTOF	splash10-0a4j-9000000000-580658c1ae323fa4f718	2015-04-24	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Negative-QTOF	splash10-016r-6900000000-4a0e75761c8eb8071d1e	2015-04-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Negative-QTOF	splash10-004i-9100000000-7e5e1e00ef8f891ffe3e	2015-04-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 40V, Negative-QTOF	splash10-004i-9000000000-08f155d8875692abc94b	2015-04-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Positive-QTOF	splash10-00di-7900000000-fec8dd084ee59efa2286	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Positive-QTOF	splash10-0kmi-9800000000-beb639c3fffc815897cc	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 40V, Positive-QTOF	splash10-0a4j-9000000000-580658c1ae323fa4f718	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Negative-QTOF	splash10-016r-6900000000-4a0e75761c8eb8071d1e	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Negative-QTOF	splash10-004i-9100000000-7e5e1e00ef8f891ffe3e	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 40V, Negative-QTOF	splash10-004i-9000000000-08f155d8875692abc94b	2015-05-27	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Negative-QTOF	splash10-004i-9100000000-83b3c3bba9003d67c444	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Negative-QTOF	splash10-004i-9000000000-a5e502a2627af2048a1f	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 40V, Negative-QTOF	splash10-004i-9000000000-a5e502a2627af2048a1f	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 10V, Positive-QTOF	splash10-0fdk-9800000000-dad61e875fa6524224d8	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Dihydroxyacetone phosphate 20V, Positive-QTOF	splash10-007k-9200000000-3ce8b7e1264e4e13f792	2021-09-25	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum

IR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)	2023-02-03	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)	2023-02-03	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)	2023-02-03	FELIX lab	View Spectrum

Biological Properties

Cellular Locations

Peroxisome

Biospecimen Locations

Blood
Cellular Cytoplasm
Saliva

Tissue Locations

Placenta

Pathways

Name	SMPDB/PathBank	KEGG
Fructose and mannose metabolism	Not Available
Glycerol Phosphate Shuttle		Not Available
Oxidative phosphorylation	Not Available
Phospholipid Biosynthesis
Glycerolipid Metabolism

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	12.1 +/- 5.1 uM	Newborn (0-30 days old)	Both	Normal	Geigy Scientific ...	details
Blood	Detected and Quantified	15.6 +/- 4.56 uM	Adult (>18 years old)	Both	Normal	12881455	details
Cellular Cytoplasm	Detected and Quantified	140 (60-220) uM	Adult (>18 years old)	Both	Normal	15882454	details
Saliva	Detected and Quantified	10.33 +/- 5.13 uM	Adult (>18 years old)	Female	Normal	23857558	details
Saliva	Detected and Quantified	1.87 +/- 0.809 uM	Adult (>18 years old)	Both	Normal	Sugimoto et al. (...	details
Saliva	Detected and Quantified	2.08 +/- 1.62 uM	Adult (>18 years old)	Male	Normal	Sugimoto et al. (...	details
Saliva	Detected and Quantified	3.00 +/- 1.57 uM	Adult (>18 years old)	Both	Normal	Sugimoto et al. (...	details
Saliva	Detected and Quantified	3.68 +/- 1.39 uM	Adult (>18 years old)	Female	Normal	Sugimoto et al. (...	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	1.88 +/- 0.34 uM	Adult (>18 years old)	Both	Transaldolase deficiency	12881455	details
Saliva	Detected and Quantified	8.45 +/- 4.68 uM	Adult (>18 years old)	Male	Alzheimer's disease	23857558	details
Saliva	Detected and Quantified	10.80 +/- 9.74 uM	Adult (>18 years old)	Male	Frontotemporal lobe dementia	23857558	details
Saliva	Detected and Quantified	8.71 +/- 3.88 uM	Adult (>18 years old)	Both	Lewy body disease	23857558	details

Associated Disorders and Diseases

Disease References

Transaldolase deficiency
Huck JH, Struys EA, Verhoeven NM, Jakobs C, van der Knaap MS: Profiling of pentose phosphate pathway intermediates in blood spots by tandem mass spectrometry: application to transaldolase deficiency. Clin Chem. 2003 Aug;49(8):1375-80. [PubMed:12881455 ]
Alzheimer's disease
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Frontotemporal dementia
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Lewy body disease
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]

Associated OMIM IDs

606003 (Transaldolase deficiency)
104300 (Alzheimer's disease)
600274 (Frontotemporal dementia)

External Links

DrugBank ID

DB04326

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

DIHYDROXY-ACETONE-PHOSPHATE

BiGG ID

33898

Wikipedia Link

Dihydroxyacetone_phosphate

METLIN ID

6262

PubChem Compound

668

PDB ID

Not Available

ChEBI ID

16108

Food Biomarker Ontology

Not Available

VMH ID

DHAP

MarkerDB ID

MDB00000328

Good Scents ID

Not Available

References

Synthesis Reference

Ballou, Clinton E.; Fischer, Hermann O. L. The synthesis of dihydroxyacetone phosphate. Journal of the American Chemical Society (1956), 78 1659-61.

Material Safety Data Sheet (MSDS)

Not Available

General References

Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18. [PubMed:15882454 ]
Roberts NB, Dutton J, Helliwell T, Rothwell PJ, Kavanagh JP: Pyrophosphate in synovial fluid and urine and its relationship to urinary risk factors for stone disease. Ann Clin Biochem. 1992 Sep;29 ( Pt 5):529-34. [PubMed:1332571 ]
Yamamoto T, Moriwaki Y, Takahashi S, Ohata H, Nakano T, Yamakita J, Higashino K: Effect of glucagon on the xylitol-induced increase in the plasma concentration and urinary excretion of purine bases. Metabolism. 1996 Nov;45(11):1354-9. [PubMed:8931639 ]
Schutgens RB, Wanders RJ, Heymans HS, Schram AW, Tager JM, Schrakamp G, van den Bosch H: Zellweger syndrome: biochemical procedures in diagnosis, prevention and treatment. J Inherit Metab Dis. 1987;10 Suppl 1:33-45. [PubMed:3119940 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Only showing the first 10 proteins. There are 14 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Alkaline phosphatase, placental type

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: ALPP
Uniprot ID:: P05187
Molecular weight:: 57953.31

Enzyme Details

2. Intestinal-type alkaline phosphatase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: ALPI
Uniprot ID:: P09923
Molecular weight:: 56811.695

Enzyme Details

3. Alkaline phosphatase, tissue-nonspecific isozyme

General function:: Involved in catalytic activity
Specific function:: This isozyme may play a role in skeletal mineralization.
Gene Name:: ALPL
Uniprot ID:: P05186
Molecular weight:: 57304.435

Enzyme Details

4. Alkaline phosphatase, placental-like

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: ALPPL2
Uniprot ID:: P10696
Molecular weight:: 57376.515

Enzyme Details

5. Glycerol-3-phosphate dehydrogenase, mitochondrial

General function:: Involved in calcium ion binding
Specific function:: Not Available
Gene Name:: GPD2
Uniprot ID:: P43304
Molecular weight:: 80851.99

Reactions

Glycerol 3-phosphate + a quinone → Dihydroxyacetone phosphate + a quinol	details
Glycerol 3-phosphate + FAD → Dihydroxyacetone phosphate + FADH	details

Enzyme Details

6. Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: GPD1
Uniprot ID:: P21695
Molecular weight:: 37567.4

Reactions

Glycerol 3-phosphate + NAD → Dihydroxyacetone phosphate + NADH	details
Glycerol 3-phosphate + NAD → Dihydroxyacetone phosphate + NADH + Hydrogen Ion	details

Enzyme Details

7. Fructose-bisphosphate aldolase A

General function:: Involved in fructose-bisphosphate aldolase activity
Specific function:: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Gene Name:: ALDOA
Uniprot ID:: P04075
Molecular weight:: 39419.675

Reactions

Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Sedoheptulose 1,7-bisphosphate → Dihydroxyacetone phosphate + D-Erythrose 4-phosphate	details
Fructose 1-phosphate → Dihydroxyacetone phosphate + Glyceraldehyde	details
Dihydroxyacetone phosphate + D-Erythrose 4-phosphate → Sedoheptulose 1,7-bisphosphate	details
Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate → Fructose 1,6-bisphosphate	details

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzyme Details

8. Fructose-bisphosphate aldolase C

General function:: Involved in fructose-bisphosphate aldolase activity
Specific function:: Not Available
Gene Name:: ALDOC
Uniprot ID:: P09972
Molecular weight:: 39455.505

Reactions

Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Sedoheptulose 1,7-bisphosphate → Dihydroxyacetone phosphate + D-Erythrose 4-phosphate	details
Fructose 1-phosphate → Dihydroxyacetone phosphate + Glyceraldehyde	details

Enzyme Details

9. Fructose-bisphosphate aldolase B

General function:: Involved in fructose-bisphosphate aldolase activity
Specific function:: Not Available
Gene Name:: ALDOB
Uniprot ID:: P05062
Molecular weight:: 39472.715

Reactions

Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Fructose 1,6-bisphosphate → Dihydroxyacetone phosphate + Glyceraldehyde 3-phosphate	details
Sedoheptulose 1,7-bisphosphate → Dihydroxyacetone phosphate + D-Erythrose 4-phosphate	details
Fructose 1-phosphate → Dihydroxyacetone phosphate + Glyceraldehyde	details

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzyme Details

10. Dihydroxyacetone phosphate acyltransferase

General function:: Lipid transport and metabolism
Specific function:: Not Available
Gene Name:: GNPAT
Uniprot ID:: O15228
Molecular weight:: 77187.185

Reactions

Acyl-CoA + Dihydroxyacetone phosphate → Coenzyme A + acylglycerone phosphate	details

Only showing the first 10 proteins. There are 14 proteins in total.

Show all enzymes and transporters

Showing metabocard for Dihydroxyacetone phosphate (HMDB0001473)

MOL for HMDB0001473 (Dihydroxyacetone phosphate)

3D MOL for HMDB0001473 (Dihydroxyacetone phosphate)

3D SDF for HMDB0001473 (Dihydroxyacetone phosphate)

3D-SDF for HMDB0001473 (Dihydroxyacetone phosphate)

PDB for HMDB0001473 (Dihydroxyacetone phosphate)

3D PDB for HMDB0001473 (Dihydroxyacetone phosphate)

SMILES for HMDB0001473 (Dihydroxyacetone phosphate)

INCHI for HMDB0001473 (Dihydroxyacetone phosphate)

Structure for HMDB0001473 (Dihydroxyacetone phosphate)

3D Structure for HMDB0001473 (Dihydroxyacetone phosphate)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra

IR Spectra

Enzymes

Reactions

Reactions

Reactions

References

Reactions

Reactions

References

Reactions