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Showing metabocard for Pyrophosphate (HMDB0000250)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:39 UTC
HMDB IDHMDB0000250
Secondary Accession Numbers
  • HMDB00250
Metabolite Identification
Common NamePyrophosphate
DescriptionThe anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. The pyrophosphate anion is abbreviated PPi and is formed by the hydrolysis of ATP into AMP in cells. This hydrolysis is called pyrophosphorolysis. The pyrophosphate anion has the structure P2O74-, and is an acid anhydride of phosphate. It is unstable in aqueous solution and rapidly hydrolyzes into inorganic phosphate. Pyrophosphate is an osteotoxin (arrests bone development) and an arthritogen (promotes arthritis). It is also a metabotoxin (an endogenously produced metabolite that causes adverse health affects at chronically high levels). Chronically high levels of pyrophosphate are associated with hypophosphatasia. Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Hypophosphatasia is associated with a molecular defect in the gene encoding tissue non-specific alkaline phosphatase (TNSALP). TNSALP is an enzyme that is tethered to the outer surface of osteoblasts and chondrocytes. TNSALP hydrolyzes several substances, including inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate (PLP), a major form of vitamin B6. When TSNALP is low, inorganic pyrophosphate (PPi) accumulates outside of cells and inhibits the formation of hydroxyapatite, one of the main components of bone, causing rickets in infants and children and osteomalacia (soft bones) in adults. Vitamin B6 must be dephosphorylated by TNSALP before it can cross the cell membrane. Vitamin B6 deficiency in the brain impairs synthesis of neurotransmitters which can cause seizures. In some cases, a build-up of calcium pyrophosphate dihydrate crystals in the joints can cause pseudogout.
Structure
Data?1676999679
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000250 (Pyrophosphate)


  Mrv1652309032023582D          

  9  8  0  0  0  0            999 V2000
    0.1105   -1.2375    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  6  1  1  0  0  0  0
  7  1  1  0  0  0  0
  8  4  1  0  0  0  0
  9  4  1  0  0  0  0
M  END
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3D MOL for HMDB0000250 (Pyrophosphate)

HMDB0000250
     RDKit          3D
Pyrophosphate
 13 12  0  0  0  0  0  0  0  0999 V2000
   -1.0376    1.0501    0.7445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1797    0.0033   -0.3460 P   0  0  0  0  0  5  0  0  0  0  0  0
   -1.5735    0.8656   -1.7699 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4051   -1.0991    0.0465 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2819   -0.7810   -0.6579 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4313   -0.1489    0.4075 P   0  0  0  0  0  5  0  0  0  0  0  0
    0.7325   -0.0122    1.7563 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7767   -1.1549    0.5258 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9476    1.3832   -0.0940 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4570    0.5804   -2.0621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1416   -0.5613    0.4467 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4130   -0.7010    1.1492 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2116    2.0335   -0.1467 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  6  9  1  0
  3 10  1  0
  4 11  1  0
  8 12  1  0
  9 13  1  0
M  END
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3D SDF for HMDB0000250 (Pyrophosphate)


  Mrv1652309032023582D          

  9  8  0  0  0  0            999 V2000
    0.1105   -1.2375    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  6  1  1  0  0  0  0
  7  1  1  0  0  0  0
  8  4  1  0  0  0  0
  9  4  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000250

> <DATABASE_NAME>
hmdb

> <SMILES>
OP(O)(=O)OP(O)(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)

> <INCHI_KEY>
XPPKVPWEQAFLFU-UHFFFAOYSA-N

> <FORMULA>
H4O7P2

> <MOLECULAR_WEIGHT>
177.9751

> <EXACT_MASS>
177.943225506

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
13

> <JCHEM_AVERAGE_POLARIZABILITY>
10.276038338742834

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(phosphonooxy)phosphonic acid

> <JCHEM_LOGP>
-1.4419023016666666

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
3.060391741362254

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.7026764435673858

> <JCHEM_POLAR_SURFACE_AREA>
124.29000000000002

> <JCHEM_REFRACTIVITY>
25.5248

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
pyrophosphoric acid

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0000250 (Pyrophosphate)

HMDB0000250
     RDKit          3D
Pyrophosphate
 13 12  0  0  0  0  0  0  0  0999 V2000
   -1.0376    1.0501    0.7445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1797    0.0033   -0.3460 P   0  0  0  0  0  5  0  0  0  0  0  0
   -1.5735    0.8656   -1.7699 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4051   -1.0991    0.0465 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2819   -0.7810   -0.6579 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4313   -0.1489    0.4075 P   0  0  0  0  0  5  0  0  0  0  0  0
    0.7325   -0.0122    1.7563 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7767   -1.1549    0.5258 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9476    1.3832   -0.0940 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4570    0.5804   -2.0621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1416   -0.5613    0.4467 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4130   -0.7010    1.1492 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2116    2.0335   -0.1467 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  6  9  1  0
  3 10  1  0
  4 11  1  0
  8 12  1  0
  9 13  1  0
M  END
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PDB for HMDB0000250 (Pyrophosphate)

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  P   UNK     0       0.206  -2.310   0.000  0.00  0.00           P+0
HETATM    2  O   UNK     0      -1.127  -3.080   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0       1.540  -1.540   0.000  0.00  0.00           O+0
HETATM    4  P   UNK     0       1.540   0.000   0.000  0.00  0.00           P+0
HETATM    5  O   UNK     0       1.540   1.540   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0       0.976  -3.644   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0      -0.564  -0.976   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       3.080   0.000   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
CONECT    1    2    3    6    7                                             
CONECT    2    1                                                            
CONECT    3    1    4                                                       
CONECT    4    3    5    8    9                                             
CONECT    5    4                                                            
CONECT    6    1                                                            
CONECT    7    1                                                            
CONECT    8    4                                                            
CONECT    9    4                                                            
MASTER        0    0    0    0    0    0    0    0    9    0   16    0
END
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3D PDB for HMDB0000250 (Pyrophosphate)

COMPND    HMDB0000250
HETATM    1  O1  UNL     1      -1.038   1.050   0.745  1.00  0.00           O  
HETATM    2  P1  UNL     1      -1.180   0.003  -0.346  1.00  0.00           P  
HETATM    3  O2  UNL     1      -1.574   0.866  -1.770  1.00  0.00           O  
HETATM    4  O3  UNL     1      -2.405  -1.099   0.047  1.00  0.00           O  
HETATM    5  O4  UNL     1       0.282  -0.781  -0.658  1.00  0.00           O  
HETATM    6  P2  UNL     1       1.431  -0.149   0.407  1.00  0.00           P  
HETATM    7  O5  UNL     1       0.733  -0.012   1.756  1.00  0.00           O  
HETATM    8  O6  UNL     1       2.777  -1.155   0.526  1.00  0.00           O  
HETATM    9  O7  UNL     1       1.948   1.383  -0.094  1.00  0.00           O  
HETATM   10  H1  UNL     1      -2.457   0.580  -2.062  1.00  0.00           H  
HETATM   11  H2  UNL     1      -3.142  -0.561   0.447  1.00  0.00           H  
HETATM   12  H3  UNL     1       3.413  -0.701   1.149  1.00  0.00           H  
HETATM   13  H4  UNL     1       1.212   2.033  -0.147  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4    5
CONECT    3   10
CONECT    4   11
CONECT    5    6
CONECT    6    7    7    8    9
CONECT    8   12
CONECT    9   13
END
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SMILES for HMDB0000250 (Pyrophosphate)

OP(O)(=O)OP(O)(O)=O
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INCHI for HMDB0000250 (Pyrophosphate)

InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
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View in JSmolView Stereo Labels
Synonyms
ValueSource
[(HO)2P(O)OP(O)(OH)2]ChEBI
Acide diphosphoriqueChEBI
DiphosphorsaeureChEBI
H4P2O7ChEBI
Pyrophosphoric acidChEBI
PyrophosphorsaeureChEBI
Diphosphoric acidKegg
PPiKegg
DiphosphateGenerator
PYROphosphATEChEBI
Na4p2O7MeSH, HMDB
PPi CPDMeSH, HMDB
Chemical FormulaH4O7P2
Average Molecular Weight177.9751
Monoisotopic Molecular Weight177.943225506
IUPAC Name(phosphonooxy)phosphonic acid
Traditional Namepyrophosphoric acid
CAS Registry Number14000-31-8
SMILES
OP(O)(=O)OP(O)(O)=O
InChI Identifier
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
InChI KeyXPPKVPWEQAFLFU-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal pyrophosphates
Direct ParentNon-metal pyrophosphates
Alternative Parents
Substituents
  • Non-metal pyrophosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effectNot Available
DispositionNot Available
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point61 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP-1.4ChemAxon
pKa (Strongest Acidic)1.7ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area124.29 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity25.52 m³·mol⁻¹ChemAxon
Polarizability10.28 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+137.21331661259
DarkChem[M-H]-129.17331661259
AllCCS[M+H]+140.44132859911
AllCCS[M-H]-126.72232859911
DeepCCS[M+H]+92.04630932474
DeepCCS[M-H]-88.55530932474
DeepCCS[M-2H]-125.85930932474
DeepCCS[M+Na]+100.58230932474
AllCCS[M+H]+140.432859911
AllCCS[M+H-H2O]+136.632859911
AllCCS[M+NH4]+144.032859911
AllCCS[M+Na]+145.032859911
AllCCS[M-H]-126.732859911
AllCCS[M+Na-2H]-129.632859911
AllCCS[M+HCOO]-132.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PyrophosphateOP(O)(=O)OP(O)(O)=O2996.9Standard polar33892256
PyrophosphateOP(O)(=O)OP(O)(O)=O1539.9Standard non polar33892256
PyrophosphateOP(O)(=O)OP(O)(O)=O1576.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Pyrophosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O)O1707.5Semi standard non polar33892256
Pyrophosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O)O1619.8Standard non polar33892256
Pyrophosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O)O2406.6Standard polar33892256
Pyrophosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O)O1727.8Semi standard non polar33892256
Pyrophosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O)O1745.4Standard non polar33892256
Pyrophosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O)O2085.9Standard polar33892256
Pyrophosphate,2TMS,isomer #2C[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C1707.6Semi standard non polar33892256
Pyrophosphate,2TMS,isomer #2C[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C1695.4Standard non polar33892256
Pyrophosphate,2TMS,isomer #2C[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C2101.0Standard polar33892256
Pyrophosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1712.4Semi standard non polar33892256
Pyrophosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1768.3Standard non polar33892256
Pyrophosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1946.9Standard polar33892256
Pyrophosphate,4TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1771.1Semi standard non polar33892256
Pyrophosphate,4TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1798.7Standard non polar33892256
Pyrophosphate,4TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1814.7Standard polar33892256
Pyrophosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O1971.0Semi standard non polar33892256
Pyrophosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O1837.6Standard non polar33892256
Pyrophosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O2549.1Standard polar33892256
Pyrophosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O)O2163.0Semi standard non polar33892256
Pyrophosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O)O2117.0Standard non polar33892256
Pyrophosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O)O2375.6Standard polar33892256
Pyrophosphate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C(C)(C)C2149.1Semi standard non polar33892256
Pyrophosphate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C(C)(C)C2140.2Standard non polar33892256
Pyrophosphate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O)O[Si](C)(C)C(C)(C)C2412.2Standard polar33892256
Pyrophosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2308.3Semi standard non polar33892256
Pyrophosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2302.0Standard non polar33892256
Pyrophosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2297.6Standard polar33892256
Pyrophosphate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2492.5Semi standard non polar33892256
Pyrophosphate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2419.1Standard non polar33892256
Pyrophosphate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2236.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-EI-TOF (Non-derivatized)splash10-0002-0972000000-a80f120dd426991d6eff2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-EI-TOF (Non-derivatized)splash10-0udi-0741900000-9c5b3c334561dd2821162017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-EI-TOF (Non-derivatized)splash10-03di-0920000000-a5ad76aa129d898d71f82017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-EI-TOF (Non-derivatized)splash10-03di-0910000000-531d3e19493dc29d6e5c2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-MS (4 TMS)splash10-0udi-0320900000-0abbcb28a43d7e24fe812018-05-17HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Pyrophosphate GC-MS (Non-derivatized)splash10-0udi-0320900000-0abbcb28a43d7e24fe812018-05-17HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pyrophosphate GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9200000000-47d5c2340766aaf36e952016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pyrophosphate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-004j-5900000000-6633d5123eb37c2662472018-05-17HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-0002-9000000000-1274b83242b279e9dac72018-05-17HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-001i-9000000000-69bc4c795fec87fef4b82018-05-17HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 1V, negative-QTOFsplash10-0udi-0009000000-0d7e21d878a866bb58ce2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 2V, negative-QTOFsplash10-0a4i-0009000000-886725ef1e6e856bba4e2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 3V, negative-QTOFsplash10-0udi-0009000000-6ea52df356fc0219aae72020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 4V, negative-QTOFsplash10-0udi-0009000000-bb05c17fd2d302e48d472020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 5V, negative-QTOFsplash10-0udi-0109000000-884206603f4eb302c1002020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 6V, negative-QTOFsplash10-0udi-0109000000-f6479c3c70cf1da434a72020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 7V, negative-QTOFsplash10-0udi-0219000000-8c9d253d3347c2b2a7b12020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 8V, negative-QTOFsplash10-0ufr-0529000000-40db63b6f9bc6df642592020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 9V, negative-QTOFsplash10-0a6r-0938000000-128abea42399dbbd6b732020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 10V, negative-QTOFsplash10-004i-0923000000-bf96528807a30d13e9412020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 11V, negative-QTOFsplash10-004i-0922000000-7ba3aaba52e7bda31d592020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 12V, negative-QTOFsplash10-004i-0911000000-729a221aabae27701a802020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 13V, negative-QTOFsplash10-004i-0910000000-2fc64e199062885202b22020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 14V, negative-QTOFsplash10-004i-0910000000-0d1641e2522b985110a82020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 15V, negative-QTOFsplash10-004i-0910000000-fca1eea6589ac6828b322020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pyrophosphate QqQ 16V, negative-QTOFsplash10-004i-0900000000-6fae5d4a6887e1ace2012020-07-22HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 10V, Positive-QTOFsplash10-004j-4900000000-fab623ebd43ab1452b9f2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 20V, Positive-QTOFsplash10-0002-9400000000-b2565f0d436385569cff2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 40V, Positive-QTOFsplash10-000t-9300000000-ac978f84efc222da7b432015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 10V, Negative-QTOFsplash10-004i-0900000000-21c64963e1ff18b360e12015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 20V, Negative-QTOFsplash10-004i-9700000000-54e41043f009fe6db86c2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pyrophosphate 40V, Negative-QTOFsplash10-004i-9000000000-2a5f69c16aa671275a622015-09-15Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biospecimen Locations
  • Blood
  • Saliva
  • Urine
Tissue Locations
  • Epidermis
  • Fibroblasts
  • Intestine
  • Neuron
  • Platelet
  • Prostate
  • Skeletal Muscle
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified1.8 (0.64-2.96) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal		 details
UrineDetected and Quantified2.56 +/- 1.22 umol/mmol creatinineChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
 details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothBladder cancer details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB04160
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDC00019561
Chemspider IDNot Available
KEGG Compound IDC00013
BioCyc IDPPI
BiGG IDNot Available
Wikipedia LinkPyrophosphate
METLIN IDNot Available
PubChem Compound1023
PDB IDNot Available
ChEBI ID29888
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceDittmer, Donald C.; Silverstein, V. Opshelor. Production of pyrophosphate from S-n-butyl phosphorothioate. Journal of Organic Chemistry (1961), 26 4706-7.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. [PubMed:15871634 ]
  2. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
  3. Broll H: [Effect of chloroquine diphosphate on the superhelix structure of DNA and protein synthesis in synovial cells in chronic polyarthritis]. Wien Klin Wochenschr. 1983 Dec 23;95(24):877-80. [PubMed:6670282 ]
  4. Golanski J, Pluta J, Baraniak J, Watala C: Limited usefulness of the PFA-100 for the monitoring of ADP receptor antagonists--in vitro experience. Clin Chem Lab Med. 2004 Jan;42(1):25-9. [PubMed:15061376 ]
  5. Mateos-Trigos G, Evans RJ, Heath MF: Effects of P2Y(1) and P2Y(12) receptor antagonists on ADP-induced shape change of equine platelets: comparison with human platelets. Platelets. 2002 Aug-Sep;13(5-6):285-92. [PubMed:12189014 ]
  6. Sirkis SI: [Serum and cerebrospinal fluid enzyme spectra in meningitis and their differential diagnostic value]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(2):193-7. [PubMed:7072418 ]
  7. Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B: FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology. 2003 Jun;124(7):1926-40. [PubMed:12806625 ]
  8. March JG, Simonet BM, Grases F: Determination of pyrophosphate in renal calculi and urine by means of an enzymatic method. Clin Chim Acta. 2001 Dec;314(1-2):187-94. [PubMed:11718694 ]
  9. Namiki M, Kitamura M, Nonomura N, Sugao H, Nakamura M, Okuyama A, Utsunomiya M, Itatani H, Matsumoto K, Sonoda T: Direct inhibitory effect of estrogen on the human testis in vitro. Arch Androl. 1988;20(2):131-5. [PubMed:3395157 ]
  10. Pickett DA, Welch DF: Recognition of Staphylococcus saprophyticus in urine cultures by screening colonies for production of phosphatase. J Clin Microbiol. 1985 Mar;21(3):310-3. [PubMed:2984240 ]
  11. Hua HT, Albadawi H, Entabi F, Conrad M, Stoner MC, Meriam BT, Sroufe R, Houser S, Lamuraglia GM, Watkins MT: Polyadenosine diphosphate-ribose polymerase inhibition modulates skeletal muscle injury following ischemia reperfusion. Arch Surg. 2005 Apr;140(4):344-51; discussion 351-2. [PubMed:15837884 ]
  12. Dahlmann N, Ueckermann C: Separation of deoxythymidine-5'-triphosphatase from unspecific hydrolases. A recommended micromethod in the diagnostic evaluation of human carcinoma. Anticancer Res. 1984 Jul-Oct;4(4-5):299-303. [PubMed:6091528 ]
  13. Ebadi M, Sharma SK, Ghafourifar P, Brown-Borg H, El Refaey H: Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins. Methods Enzymol. 2005;396:276-98. [PubMed:16291239 ]
  14. Tallaksen CM, Sande A, Bohmer T, Bell H, Karlsen J: Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Eur J Clin Pharmacol. 1993;44(1):73-8. [PubMed:8436160 ]
  15. Zhong D, Meins J, Scheidel B, Blume H: [Development of an HPLC method for determination of chloroquine in plasma]. Pharmazie. 1993 May;48(5):349-52. [PubMed:8327563 ]
  16. Recio JA, Paez JG, Maskeri B, Loveland M, Velasco JA, Notario V: Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1. Cancer Res. 2000 Mar 15;60(6):1720-8. [PubMed:10749145 ]
  17. Puri RN, Colman RF, Colman RW: Modulation of platelet responses by 2-[3-(bromo-2-oxopropylthio)]adenosine-5'-diphosphate involves its binding to as well as covalent modification of an ADP-receptor, aggregin. Arch Biochem Biophys. 1997 Jul 1;343(1):140-5. [PubMed:9210656 ]
  18. Hamagishi Y, Oki T, Tone H, Inui T: A radioimmunoassay for guanosine-5'-diphosphate-3'-diphosphate and adenosine-5'-triphosphate-3'-diphosphate. J Biochem. 1980 Dec;88(6):1785-92. [PubMed:6780546 ]
  19. Lee AY, Youm YH, Kim NH, Yang H, Choi WI: Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. Br J Dermatol. 2004 Nov;151(5):995-1003. [PubMed:15541077 ]
  20. Ito H, Yamamoto H, Kimura Y, Kambe H, Okochi T, Kishimoto S: Affinity chromatography of human plasma gelsolin with polyphosphate compounds on immobilized Cibacron Blue F3GA. J Chromatogr. 1990 Apr 6;526(2):397-406. [PubMed:2163407 ]

Only showing the first 10 proteins. There are 351 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Acetyl-coenzyme A synthetase, cytoplasmic
General function:
Involved in acetate-CoA ligase activity
Specific function:
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:
ACSS2
Uniprot ID:
Q9NR19
Molecular weight:
78579.11
Reactions
Adenosine triphosphate + Acetic acid + Coenzyme A → Adenosine monophosphate + Pyrophosphate + Acetyl-CoAdetails
Adenosine triphosphate + Acetic acid → Pyrophosphate + Acetyl adenylatedetails
Adenosine triphosphate + Propionic acid → Pyrophosphate + Propinol adenylatedetails
Enzyme Details
2. Acetyl-coenzyme A synthetase 2-like, mitochondrial
General function:
Involved in acetate-CoA ligase activity
Specific function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Molecular weight:
74625.88
Reactions
Adenosine triphosphate + Acetic acid + Coenzyme A → Adenosine monophosphate + Pyrophosphate + Acetyl-CoAdetails
Adenosine triphosphate + Acetic acid → Pyrophosphate + Acetyl adenylatedetails
Adenosine triphosphate + Propionic acid → Pyrophosphate + Propinol adenylatedetails
Enzyme Details
3. Serum paraoxonase/lactonase 3
General function:
Involved in arylesterase activity
Specific function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular weight:
39607.185
Enzyme Details
4. Fucose-1-phosphate guanylyltransferase
General function:
Involved in fucose-1-phosphate guanylyltransferase acti
Specific function:
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
Gene Name:
FPGT
Uniprot ID:
O14772
Molecular weight:
37630.405
Reactions
Guanosine triphosphate + Fucose 1-phosphate → Pyrophosphate + GDP-L-fucosedetails
Enzyme Details
5. Squalene synthase
General function:
Involved in transferase activity
Specific function:
Not Available
Gene Name:
FDFT1
Uniprot ID:
P37268
Molecular weight:
48114.87
Reactions
Farnesyl pyrophosphate + NAD(P)H → Squalene + Pyrophosphate + NAD(P)(+)details
Farnesyl pyrophosphate → Pyrophosphate + Presqualene diphosphatedetails
Presqualene diphosphate + NADPH + Hydrogen Ion → Pyrophosphate + Squalene + NADPdetails
Farnesyl pyrophosphate + NADPH + Hydrogen Ion → Squalene + Pyrophosphate + NADPdetails
Enzyme Details
6. Phenylalanine--tRNA ligase alpha subunit
General function:
Involved in nucleotide binding
Specific function:
Not Available
Gene Name:
FARSA
Uniprot ID:
Q9Y285
Molecular weight:
57563.225
Reactions
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe)details
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe)details
Enzyme Details
7. Phenylalanine--tRNA ligase, mitochondrial
General function:
Involved in nucleotide binding
Specific function:
Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
Gene Name:
FARS2
Uniprot ID:
O95363
Molecular weight:
52356.21
Reactions
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe)details
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe)details
Enzyme Details
8. Alpha-aminoadipic semialdehyde dehydrogenase
General function:
Involved in oxidoreductase activity
Specific function:
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:
ALDH7A1
Uniprot ID:
P49419
Molecular weight:
58486.74
Reactions
Aminoadipic acid + Adenosine triphosphate → L-2-Aminoadipate adenylate + Pyrophosphatedetails
Enzyme Details
9. Amidophosphoribosyltransferase
General function:
Involved in amidophosphoribosyltransferase activity
Specific function:
Not Available
Gene Name:
PPAT
Uniprot ID:
Q06203
Molecular weight:
57398.52
Reactions
5-Phosphoribosylamine + Pyrophosphate + L-Glutamic acid → L-Glutamine + Phosphoribosyl pyrophosphate + Waterdetails
Enzyme Details
10. Nicotinamide mononucleotide adenylyltransferase 1
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Gene Name:
NMNAT1
Uniprot ID:
Q9HAN9
Molecular weight:
31932.22
Reactions
Adenosine triphosphate + Nicotinamide ribotide → Pyrophosphate + NADdetails
Adenosine triphosphate + beta-nicotinate-D-ribonucleotide → Pyrophosphate + Nicotinic acid adenine dinucleotidedetails
Adenosine triphosphate + Nicotinic acid mononucleotide → Pyrophosphate + Nicotinic acid adenine dinucleotidedetails

Only showing the first 10 proteins. There are 351 proteins in total.

Show all enzymes and transporters