Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2005-11-16 15:48:42 UTC |
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Update Date | 2023-05-30 20:56:00 UTC |
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HMDB ID | HMDB0000193 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Isocitric acid |
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Description | Isocitric acid, also known as isocitrate belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups. Isocitric acid is a TCA (tricarboxylic acid) cycle intermediate. It is a structural isomer of citric acid and is formed from citrate with the help of the enzyme aconitase. More specifically, Isocitric acid is synthesized from citric acid via the intermediate cis-aconitic acid by the enzyme aconitase (aconitate hydratase). Isocitrate is acted upon by isocitrate dehydrogenase (IDH) to form alpha-ketoglutarate. This is a two-step process, which involves oxidation of isocitrate to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome. Isocitric acid exists in all living species, ranging from bacteria to plants to humans. Isocitric acid is a minor organic acid found in most fruit juices, especially in blackberries, youngberries, and boyberries, and in vegetables, especially in carrots. The determination of D-isocitric acid has become of importance in the analysis of fruit juices for the detection of illegal additives (adulteration). Since the quantities of citric and isocitric acids are correlated in fruit juices, a high ratio of citric to isocitric acid can indicate the addition of citric acid as an alduterant. In authentic orange juice, for example, the ratio of citric acid to D-isocitric acid is usually less than 130. Isocitric acid is mostly used in the food industry (food additive) as a food acidulant. |
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Structure | OC(C(CC(O)=O)C(O)=O)C(O)=O InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) |
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Synonyms | Value | Source |
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1-Hydroxypropane-1,2,3-tricarboxylic acid | ChEBI | 1-Hydroxytricarballylic acid | ChEBI | 1-Hydroxypropane-1,2,3-tricarboxylate | Generator | 1-Hydroxytricarballylate | Generator | Isocitrate | Generator | 1-Hydroxy-1,2,3-propanetricarboxylate | HMDB | 1-Hydroxy-1,2,3-propanetricarboxylic acid | HMDB | 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylate | HMDB | 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid | HMDB | 3-Carboxy-2,3-dideoxy-pentarate | HMDB | 3-Carboxy-2,3-dideoxy-pentaric acid | HMDB | D-Isocitrate | HMDB | I-cit | HMDB | Threo-D(S)-iso-citrate | HMDB | Threo-DS-isocitrate | HMDB | Isocitric acid, sodium salt | HMDB | Isocitric acid, trisodium salt | HMDB | Isocitric acid, disodium salt | HMDB | Isocitric acid, (11)C-labeled | HMDB | Isocitric acid, calcium salt | HMDB | Isocitric acid, potassium salt | HMDB |
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Chemical Formula | C6H8O7 |
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Average Molecular Weight | 192.1235 |
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Monoisotopic Molecular Weight | 192.02700261 |
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IUPAC Name | 1-hydroxypropane-1,2,3-tricarboxylic acid |
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Traditional Name | isocitric acid |
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CAS Registry Number | 320-77-4 |
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SMILES | OC(C(CC(O)=O)C(O)=O)C(O)=O |
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InChI Identifier | InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) |
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InChI Key | ODBLHEXUDAPZAU-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Tricarboxylic acids and derivatives |
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Direct Parent | Tricarboxylic acids and derivatives |
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Alternative Parents | |
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Substituents | - Tricarboxylic acid or derivatives
- Beta-hydroxy acid
- Monosaccharide
- Hydroxy acid
- Alpha-hydroxy acid
- Secondary alcohol
- Carboxylic acid
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Alcohol
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 162 - 165 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 466 mg/mL | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Experimental Collision Cross Sections |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Isocitric acid,1TMS,isomer #1 | C[Si](C)(C)OC(C(=O)O)C(CC(=O)O)C(=O)O | 1727.0 | Semi standard non polar | 33892256 | Isocitric acid,1TMS,isomer #2 | C[Si](C)(C)OC(=O)CC(C(=O)O)C(O)C(=O)O | 1715.6 | Semi standard non polar | 33892256 | Isocitric acid,1TMS,isomer #3 | C[Si](C)(C)OC(=O)C(CC(=O)O)C(O)C(=O)O | 1720.3 | Semi standard non polar | 33892256 | Isocitric acid,1TMS,isomer #4 | C[Si](C)(C)OC(=O)C(O)C(CC(=O)O)C(=O)O | 1702.5 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #1 | C[Si](C)(C)OC(=O)C(O[Si](C)(C)C)C(CC(=O)O)C(=O)O | 1763.5 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #2 | C[Si](C)(C)OC(=O)CC(C(=O)O)C(O[Si](C)(C)C)C(=O)O | 1759.1 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #3 | C[Si](C)(C)OC(=O)C(CC(=O)O)C(O[Si](C)(C)C)C(=O)O | 1779.8 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #4 | C[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C)C(O)C(=O)O | 1755.5 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #5 | C[Si](C)(C)OC(=O)CC(C(=O)O)C(O)C(=O)O[Si](C)(C)C | 1737.8 | Semi standard non polar | 33892256 | Isocitric acid,2TMS,isomer #6 | C[Si](C)(C)OC(=O)C(O)C(CC(=O)O)C(=O)O[Si](C)(C)C | 1754.5 | Semi standard non polar | 33892256 | Isocitric acid,3TMS,isomer #1 | C[Si](C)(C)OC(=O)CC(C(=O)O)C(O[Si](C)(C)C)C(=O)O[Si](C)(C)C | 1791.9 | Semi standard non polar | 33892256 | Isocitric acid,3TMS,isomer #2 | C[Si](C)(C)OC(=O)C(CC(=O)O)C(O[Si](C)(C)C)C(=O)O[Si](C)(C)C | 1794.3 | Semi standard non polar | 33892256 | Isocitric acid,3TMS,isomer #3 | C[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C)C(O[Si](C)(C)C)C(=O)O | 1795.8 | Semi standard non polar | 33892256 | Isocitric acid,3TMS,isomer #4 | C[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C)C(O)C(=O)O[Si](C)(C)C | 1776.9 | Semi standard non polar | 33892256 | Isocitric acid,4TMS,isomer #1 | C[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C)C(O[Si](C)(C)C)C(=O)O[Si](C)(C)C | 1864.1 | Semi standard non polar | 33892256 | Isocitric acid,1TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC(C(=O)O)C(CC(=O)O)C(=O)O | 1978.9 | Semi standard non polar | 33892256 | Isocitric acid,1TBDMS,isomer #2 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O)C(O)C(=O)O | 1971.6 | Semi standard non polar | 33892256 | Isocitric acid,1TBDMS,isomer #3 | CC(C)(C)[Si](C)(C)OC(=O)C(CC(=O)O)C(O)C(=O)O | 1972.5 | Semi standard non polar | 33892256 | Isocitric acid,1TBDMS,isomer #4 | CC(C)(C)[Si](C)(C)OC(=O)C(O)C(CC(=O)O)C(=O)O | 1960.3 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC(=O)C(O[Si](C)(C)C(C)(C)C)C(CC(=O)O)C(=O)O | 2198.1 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #2 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O)C(O[Si](C)(C)C(C)(C)C)C(=O)O | 2193.1 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #3 | CC(C)(C)[Si](C)(C)OC(=O)C(CC(=O)O)C(O[Si](C)(C)C(C)(C)C)C(=O)O | 2210.3 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #4 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C(C)(C)C)C(O)C(=O)O | 2216.3 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #5 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O)C(O)C(=O)O[Si](C)(C)C(C)(C)C | 2202.8 | Semi standard non polar | 33892256 | Isocitric acid,2TBDMS,isomer #6 | CC(C)(C)[Si](C)(C)OC(=O)C(O)C(CC(=O)O)C(=O)O[Si](C)(C)C(C)(C)C | 2207.8 | Semi standard non polar | 33892256 | Isocitric acid,3TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O)C(O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C | 2433.8 | Semi standard non polar | 33892256 | Isocitric acid,3TBDMS,isomer #2 | CC(C)(C)[Si](C)(C)OC(=O)C(CC(=O)O)C(O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C | 2449.2 | Semi standard non polar | 33892256 | Isocitric acid,3TBDMS,isomer #3 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C(=O)O | 2451.0 | Semi standard non polar | 33892256 | Isocitric acid,3TBDMS,isomer #4 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C(C)(C)C)C(O)C(=O)O[Si](C)(C)C(C)(C)C | 2434.5 | Semi standard non polar | 33892256 | Isocitric acid,4TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC(=O)CC(C(=O)O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C | 2625.5 | Semi standard non polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS) | splash10-0002-1952000000-7c34751686a6bdb54cab | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS) | splash10-0002-0963000000-459b45ff9246b5f55914 | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized) | splash10-0002-0942000000-61204d02a28e43d21607 | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS) | splash10-00di-9420000000-4e1a59fe735855d52ce2 | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-MS (4 TMS) | splash10-00ea-3793000000-84858fa896697420275f | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Non-derivatized) | splash10-0002-1952000000-7c34751686a6bdb54cab | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Non-derivatized) | splash10-0002-0963000000-459b45ff9246b5f55914 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-EI-TOF (Non-derivatized) | splash10-00di-9420000000-4e1a59fe735855d52ce2 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Isocitric acid GC-MS (Non-derivatized) | splash10-00ea-3793000000-84858fa896697420275f | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (Non-derivatized) - 70eV, Positive | splash10-00ba-7900000000-96194d87d52b155cf1b9 | 2016-09-22 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (4 TMS) - 70eV, Positive | splash10-02vi-7029500000-2bb65fc897e48cc21750 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_1_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_1_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_1_3) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_1_4) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_3) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_4) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_5) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_2_6) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_3_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_3_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Isocitric acid GC-MS (TMS_3_3) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF | splash10-0006-0901310000-883764bf7b686ca7fd17 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF | splash10-03di-0900000000-66d03405eeb126c6ad9d | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF | splash10-00di-0900000000-cdad17a11f419421c787 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF | splash10-0udi-0009000000-d3440c84a488b3e22212 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative-QTOF | splash10-0006-0900000000-3aa263561a7a49df7d3d | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative-QTOF | splash10-0006-1900000000-3636f87026e4206a1638 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative-QTOF | splash10-01w3-9600000000-ab1a2b9a29528a623d0b | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative-QTOF | splash10-0079-9000000000-3c33cefeb87f85efd5de | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative-QTOF | splash10-059m-9000000000-34775db8bbc008018633 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ , negative-QTOF | splash10-0006-0900000000-3aa263561a7a49df7d3d | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ , negative-QTOF | splash10-0006-1900000000-3636f87026e4206a1638 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ , negative-QTOF | splash10-01w3-9600000000-ab1a2b9a29528a623d0b | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ , negative-QTOF | splash10-0079-9000000000-3c33cefeb87f85efd5de | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-QQ , negative-QTOF | splash10-059m-9000000000-34775db8bbc008018633 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT , negative-QTOF | splash10-03di-0900000000-66d03405eeb126c6ad9d | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid LC-ESI-ITFT , negative-QTOF | splash10-00di-0900000000-cdad17a11f419421c787 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid , negative-QTOF | splash10-03k9-2900000000-e5336d859bf90bcd904c | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 10V, Negative-QTOF | splash10-03k9-2900000000-8ef1bf8afd67194ddf65 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 40V, Negative-QTOF | splash10-059f-9000000000-37227e36af9ba4db4a7e | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 20V, Negative-QTOF | splash10-022i-9500000000-cb0234d7a355d54f1755 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 10V, Negative-QTOF | splash10-03k9-3900000000-1b8cb16b24c65e87915b | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 20V, Negative-QTOF | splash10-03ki-9500000000-d264dd60719df8b72ef3 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 40V, Negative-QTOF | splash10-00di-9000000000-bf62fc70edcee073c517 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid 30V, Negative-QTOF | splash10-02mi-9200000000-42ca838ca7f08cc3882e | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Isocitric acid Quattro_QQQ 10V, Positive-QTOF (Annotated) | splash10-0udi-1900000000-8e1185b0504ea1547715 | 2012-07-24 | HMDB team, MONA | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Experimental 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, experimental) | 2012-12-04 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Experimental 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | 2012-12-05 | Wishart Lab | View Spectrum |
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Disease References | Anoxia |
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- Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. [PubMed:8579834 ]
| Alzheimer's disease |
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- Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
| Frontotemporal dementia |
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- Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
| Lewy body disease |
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- Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
| Autosomal dominant polycystic kidney disease |
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- Gronwald W, Klein MS, Zeltner R, Schulze BD, Reinhold SW, Deutschmann M, Immervoll AK, Boger CA, Banas B, Eckardt KU, Oefner PJ: Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney Int. 2011 Jun;79(11):1244-53. doi: 10.1038/ki.2011.30. Epub 2011 Mar 9. [PubMed:21389975 ]
| Eosinophilic esophagitis |
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- Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
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