| Identification |
|---|
| HMDB Protein ID
| HMDBP13459 |
| Secondary Accession Numbers
| None |
| Name
| Phosphoribosylformylglycinamidine synthase subunit PurL |
| Synonyms
|
- FGAM synthase
- Formylglycinamide ribonucleotide amidotransferase subunit II
- Glutamine amidotransferase PurL
- Phosphoribosylformylglycinamidine synthase subunit II
- FGAR amidotransferase II
- FGAR-AT II
|
| Gene Name
| PURL |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. |
| Pathways
|
- Biosynthesis of secondary metabolites
- IMP biosynthesis via de novo pathway
- Purine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| 'de novo' IMP biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| magnesium ion binding |
| ATP binding |
| phosphoribosylformylglycinamidine synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 760 |
| Molecular Weight
| 81737.975 |
| Theoretical pI
| 6.361 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q83FE8 |
| UniProtKB/Swiss-Prot Entry Name
| PURL_TROWT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Raoult D, Ogata H, Audic S, Robert C, Suhre K, Drancourt M, Claverie JM: Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome. Genome Res. 2003 Aug;13(8):1800-9. doi: 10.1101/gr.1474603. [PubMed:12902375 ]
|
