- Metabolite
- HMDB0003192 (5-Aminoimidazole-4-carboxamide)
- Biospecimen
- Blood
- Status
- Detected and Quantified
- Data source
- Referenced
- Concentration
- 5.55 (0.79 - 39.67) uM
- Age
- Adult (>18 years old)
- Sex
- Both
- Condition
- Malignant melanoma or sarcoma
Comments
After receiving 2.65-6.85 mg dacarbazine/kg body weight by intravenous bolus injection or by continuous 0.5-6-h infusions
References
- Breithaupt H, Dammann A, Aigner K: Pharmacokinetics of dacarbazine (DTIC) and its metabolite 5-aminoimidazole-4-carboxamide (AIC) following different dose schedules. Cancer Chemother Pharmacol. 1982;9(2):103-9. [PubMed:7172404 ]